Evidence map›Paper›PMID 35318909›Full record

ArticleThe British journal of psychiatry : the journal of mental science2022

Association between serum lithium level and incidence of COVID-19 infection.

Livia J De Picker, Marion Leboyer, John R Geddes, Manuel Morrens, Paul J Harrison, Maxime Taquet

Abstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Sex differences in the cardiac stress response following SARS-CoV-2 infection of ferrets.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  10. Article
  11. Long-Term Lithium Therapy: Side Effects and Interactions.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Livia J De PickerUniversity Psychiatric Hospital Duffel, Belgium and Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Belgium.ORCID 0000-0002-6883-0559
Marion LeboyerTranslational Neuropsychiatry Lab, Université Paris Est Creteil (UPEC), INSERM U955, IMRB, France; Département Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), AP-HP, Hopital Henri Mondor, France; and Fondation FondaMental, France.
John R GeddesDepartment of Psychiatry, University of Oxford, UK and Oxford Health NHS Foundation Trust, UK.
Manuel MorrensUniversity Psychiatric Hospital Duffel, Belgium and Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Belgium.
Paul J HarrisonDepartment of Psychiatry, University of Oxford, UK.ORCID 0000-0002-6719-1126
Maxime TaquetDepartment of Psychiatry, University of Oxford, UK.ORCID 0000-0002-8987-952X

Funding

Department of Health IS-BRC-1215-20005
6 · The paper itself

Abstract

An antiviral effect of lithium has been proposed, but never investigated for coronavirus disease 2019 (COVID-19). Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, we show that the 6-month COVID-19 infection incidence was lower among matched patients with 'therapeutic' (0.50-1.00) versus 'subtherapeutic' (0.05-0.50) lithium levels (hazard ratio (HR) = 0.82, 95% CI 0.69-0.97,

Indexed as

Bipolar DisorderCOVID-19Antimanic AgentsHumansIncidenceLithiumLithium CompoundsValproic AcidAntimanic AgentsLithiumLithium CompoundsValproic Acidbipolar disorderCOVID-19lithiumpsychopharmacologyvalproate

Identifiers

PMID35318909
PMCPMC7612897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.