Evidence map›Paper›PMID 35318873›Full record

ArticleRenal failure2022

Efficacy of Roxadustat on anemia and residual renal function in patients new to peritoneal dialysis.

Tong Wu, Yuanyuan Qi, Shuang Ma, Lijie Zhang, Xinyu Pu, Kui Chen, Ying Zhao, Shenghua Sang, Jing Xiao

Open access · greenAbstract read
In one paragraph

Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  8. Review
  9. Epidemiology of peritoneal dialysis outcomes.Nature reviews. Nephrology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tong WuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID 0000-0003-3302-5485
Yuanyuan QiDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shuang MaDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lijie ZhangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinyu PuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Kui ChenDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ying ZhaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shenghua SangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Jing XiaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth early correction of anemia and preserving residual renal function (RRF) are reported to improve patient survival. The aim of this study was to explore the efficacy and safety of Roxadustat for treatment of renal anemia in patients new to peritoneal dialysis (PD) and to assess its impact on RRF.

methodsA retrospective analysis was performed on 60 initial peritoneal dialysis (PD) patients with renal anemia. Twenty-eight cases were treated with Roxadustat (Roxadustat group) and 32 with recombinant human erythropoietin (control group). Clinical characteristics, hemoglobin (Hb), C-reactive protein, blood lipids, iron metabolism, dialysis adequacy and RRF of the two groups were evaluated and adverse events were recorded. All patients were followed up for at least 40 weeks.

resultsAfter 40 weeks of treatment, mean Hb levels were significantly higher from baseline values in both groups, the mean Hb change in Roxadustat group was higher than control group (3.46 ± 1.59 g/dL vs. 2.28 ± 2.27 g/dL,

conclusionIn patients new to PD, Roxadustat effectively and safely improved renal anemia and delay the decline of RRF.

Indexed as

AnemiaPeritoneal DialysisGlycineHumansIsoquinolinesKidneyRetrospective StudiesGlycineIsoquinolinesroxadustatperitoneal dialysisrenal anemiaresidual renal functionRoxadustat

Identifiers

PMID35318873
PMCPMC8956311
OpenAlexW4220726950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.