Evidence map›Paper›PMID 35318709›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2022

Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation.

Eva Morsing, Pia Lundgren, Anna-Lena Hård, Alexander Rakow, Lena Hellström-Westas, Lena Jacobson, Mats Johnson, Staffan Nilsson, Lois E H Smith, Karin Sävman and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  4. Reflections on Consciousness in Intensive Care.Acta paediatrica (Oslo, Norway : 1992) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Eva MorsingDepartment of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Pia LundgrenThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-7731-1988
Anna-Lena HårdThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-2440-2851
Alexander RakowDepartment of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Lena Hellström-WestasDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Lena JacobsonThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-8563-2127
Mats JohnsonGillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Staffan NilssonDepartment of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
Lois E H SmithDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Karin SävmanRegion Västra Götaland, Department of Neonatology, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Ann HellströmThe Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-9259-1244
Sahlgrenska University Hospital · SEKarolinska University Hospital · SEBoston Children's Hospital · USChalmers University of Technology · SELund University · SEUniversity of Gothenburg · SEUppsala University · SE

Funding

Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Glucose/lipid metabolism and vessel development in phase I ROPR01EY030904 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SMITH, LOIS · 2020 to 2023
$1.7M
De Blindas VännerGothenburg Medical SocietyGovernment grants under the ALF agreement ALFGBG-717971Knut och Alice Wallenbergs StiftelseNEI NIH HHS R01 EY017017NEI NIH HHS R01 EY030904NICHD NIH HHS P50 HD105351Swedish Medical Research Council 2016-01131
6 · The paper itself

Abstract

aimThis study investigated childhood diagnoses in children born extremely preterm before 24 weeks of gestation.

methodsDiagnoses of neurodevelopmental disorders and selected somatic diagnoses were retrospectively retrieved from national Swedish registries for children born before 24 weeks from 2007 to 2018. Their individual medical files were also examined.

resultsWe studied 383 children born at a median of 23.3 (range 21.9-23.9) weeks, with a median birthweight of 565 (range 340-874) grams. Three-quarters (75%) had neurodevelopmental disorders, including speech disorders (52%), intellectual disabilities (40%), attention deficit hyperactivity disorder (30%), autism spectrum disorders (24%), visual impairment (22%), cerebral palsy (17%), epilepsy (10%) and hearing impairment (5%). More boys than girls born at 23 weeks had intellectual disabilities (45% vs. 27%, p < 0.01) and visual impairment (25% vs. 14%, p < 0.01). Just over half of the cohort (55%) received habilitation care. The majority (88%) had somatic diagnoses, including asthma (63%) and failure to thrive/short stature (39%).

conclusionMost children born before 24 weeks had neurodevelopmental disorders and/or additional somatic diagnoses in childhood and were referred to habilitation services. Clinicians should be aware of the multiple health and developmental problems affecting these children. Resources are needed to identify their long-term support needs at an early stage.

Indexed as

Autism Spectrum DisorderIntellectual DisabilityNeurodevelopmental DisordersChildFemaleHumansInfant, NewbornMaleRetrospective StudiesVision Disordersextremely preterm birthhabilitation carelong-term supportneurodevelopmental disorderssomatic disorders

Identifiers

PMID35318709
PMCPMC9454084
OpenAlexW4220981208

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.