Evidence map›Paper›PMID 35318688›Full record

ArticleArtificial organs2022

Pulsatility hemodynamics during speed modulation of continuous-flow total artificial heart in a chronic in vivo model.

Taiyo Kuroda, Takuma Miyamoto, Chihiro Miyagi, Anthony R Polakowski, Christine R Flick, Barry D Kuban, George B Voros, Kimberly Such, Kiyotaka Fukamachi, Jamshid H Karimov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taiyo KurodaDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-9501-0639
Takuma MiyamotoDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Chihiro MiyagiDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-8986-2499
Anthony R PolakowskiDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Christine R FlickDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
Barry D KubanDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.
George B VorosBiological Resources Unit, Cleveland Clinic, Cleveland, Ohio, USA.
Kimberly SuchBiological Resources Unit, Cleveland Clinic, Cleveland, Ohio, USA.
Kiyotaka FukamachiDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-4852-8416
Jamshid H KarimovDepartment of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-0167-0415

Funding

Self Regulating Continuous Flow Total Artificial HeartR01HL096619 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FUKAMACHI, KIYOTAKA · 2010 to 2019
$10.9M
NHLBI NIH HHS 2R01HL096619NHLBI NIH HHS R01 HL096619
6 · The paper itself

Abstract

backgroundThe evaluation of pulsatile flow created by the new Cleveland Clinic continuous-flow total artificial heart (CFTAH100), which has a re-designed right impeller and motor, had not been tested in vivo. The purpose of this study was to evaluate the feasibility of pulsatility with the CFTAH100 during the application of pump speed modulation protocols in a chronic animal model.

methodsA 30-day chronic animal experiment was conducted with a calf. Five pulsatile studies were performed on the alert animal. The mean pump speed was set at 2800 rpm, and modulated sinusoidally within a range of 0 to ± 35% of mean speed, in increments of 5% at 80 beats per minute (bpm). The pressures and pump flow were collected and a pulsatility index (PI) was calculated.

resultsThe calf was supported with the CFTAH100 without any major complications. The maximum and minimum pump flows changed significantly from baseline in all conditions, while the mean pump flow did not change. All flow pulsatility (FP) readings in all conditions significantly increased from baseline, and the percent modulation (%S) and FP had a strong positive correlation (r = 0.99, p  <  0.01). The PI also increased significantly in all conditions (maximum at %S of 35%, 2.2  ±  0.05, p < 0.01), and a positive correlation between %S and PI (r = 0.99, p < 0.01) was observed.

conclusionThe CFTAH100 showed the feasibility of creating pulsatile circulation with sinusoidal pump speed modulation.

Indexed as

Heart, ArtificialHeart-Assist DevicesAnimalsHemodynamicsPulsatile Flowheart failuremechanical circulatory supportpulsatile flowpulsatility indextotal artificial heart

Identifiers

PMID35318688
PMCPMC9543567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.