Evidence map›Paper›PMID 35318510›Full record

ReviewHandbook of experimental pharmacology2022

Insights from Studies of White Adipose Tissue Using Single-Cell Approaches.

Niklas Mejhert, Mikael Rydén

Abstract readReview
PubMed Publisher
In one paragraph

Review in Handbook of experimental pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Niklas MejhertDepartment of Medicine (H7), Karolinska Institute, Stockholm, Sweden. niklas.mejhert@ki.se.
Mikael RydénDepartment of Medicine (H7), Karolinska Institute, Stockholm, Sweden. mikael.ryden@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Technologies allowing studies at single-cell resolution have provided important insights into how different cell populations contribute to tissue function. Application of these methods to white adipose tissue (WAT) has revealed how various metabolic aspects of this organ, such as insulin response, inflammation and tissue expansion, are regulated by specific WAT resident cells, including different subtypes of adipocytes, adipocyte progenitors as well as immune and endothelial cells. In this chapter, we provide an overview of the different technical approaches, their strengths and weaknesses, and summarize how these studies have improved our understanding of WAT function in health and disease.

Indexed as

Endothelial CellsInsulin ResistanceAdipocytes, WhiteAdipose TissueAdipose Tissue, WhiteHumansObesityObesitySingle-cell sequencingSingle-nucleus sequencingSpatial transcriptomicsType 2 diabetes

Identifiers

PMID35318510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.