ArticleScientific reports2022
The effects of gravity and compression on interstitial fluid transport in the lower limb.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Efficacy of vascularized lymph node transfer for lower extremity lymphedema: A systematic review and meta-analysis of 395 patients from 25 peer-reviewed studies.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2026Pooled it
- Finite Element Modeling of Lower Limb Lymphedema: Influence of Limb Morphology and Compression Garment Classes on Internal Pressure Distribution.Annals of biomedical engineering · 2026Article
- A wearable biomechanical system for medical evaluation of soft tissue disorders.Science advances · 2026Article
- Compression Therapy in Human Body Applications: A Systematic Review from Principles to Practice.Annals of biomedical engineering · 2026Review
- Bringing to Light the Invisible Lymphatic Anatomy of the Upper Extremity: Report From the 2024 Harvard Radcliffe Institute Accelerator Workshop.Annals of surgery · 2026Article
- A synergistic multimodality treatment approach to address the key drivers of wound chronicity.Journal of vascular surgery. Venous and lymphatic disorders · 2026Review
- How to perform fluid de-escalation in critical care.Annals of intensive care · 2026Review
- Patient-specific numerical simulation of compression therapy effects on interstitial fluid motion in lower limb lymphedema.Biomechanics and modeling in mechanobiology · 2025Article
- Viral Infection and Dissemination Through the Lymphatic System.Microorganisms · 2025Review
- Efficacy of a Mixture of Diosmin, Coumarin, and Arbutin on Preventing Breast Edema in Implant-Based Breast Reconstruction.Aesthetic surgery journal. Open forum · 2025Article
- The Metabolic Syndrome, a Human Disease.International journal of molecular sciences · 2024Review
- Topical captopril: a promising treatment for secondary lymphedema.Translational research : the journal of laboratory and clinical medicine · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Edema in the limbs can arise from pathologies such as elevated capillary pressures due to failure of venous valves, elevated capillary permeability from local inflammation, and insufficient fluid clearance by the lymphatic system. The most common treatments include elevation of the limb, compression wraps and manual lymphatic drainage therapy. To better understand these clinical situations, we have developed a comprehensive model of the solid and fluid mechanics of a lower limb that includes the effects of gravity. The local fluid balance in the interstitial space includes a source from the capillaries, a sink due to lymphatic clearance, and movement through the interstitial space due to both gravity and gradients in interstitial fluid pressure (IFP). From dimensional analysis and numerical solutions of the governing equations we have identified several parameter groups that determine the essential length and time scales involved. We find that gravity can have dramatic effects on the fluid balance in the limb with the possibility that a positive feedback loop can develop that facilitates chronic edema. This process involves localized tissue swelling which increases the hydraulic conductivity, thus allowing the movement of interstitial fluid vertically throughout the limb due to gravity and causing further swelling. The presence of a compression wrap can interrupt this feedback loop. We find that only by modeling the complex interplay between the solid and fluid mechanics can we adequately investigate edema development and treatment in a gravity dependent limb.
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Registered trials
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