Evidence map›Paper›PMID 35318419›Full record

ArticleScientific reports2022

Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model.

Jun Zhu, Takenori Inomata, Masahiro Nakamura, Keiichi Fujimoto, Yasutsugu Akasaki, Kenta Fujio, Ai Yanagawa, Koichiro Uchida, Jaemyoung Sung, Naoko Negishi and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Elucidation ofFrontiers in microbiology · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 3 countries.

Jun Zhu *Department of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Takenori Inomata *Department of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. tinoma@juntendo.ac.jp.
Masahiro NakamuraDepartment of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Keiichi FujimotoDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Yasutsugu AkasakiDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kenta FujioDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Ai YanagawaDepartment of Digital Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Koichiro UchidaCenter for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan.
Jaemyoung SungDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Naoko NegishiAtopy Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ken NaginoDepartment of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Yuichi OkumuraDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Maria MiuraDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hurramhon ShokirovaDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Mizu KuwaharaDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Kunihiko HirosawaDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Akie Midorikawa-InomataDepartment of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Atsuko EguchiDepartment of Hospital Administration, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Tianxiang HuangDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hideo YagitaDepartment of Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Sonoko HabuAtopy Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Ko OkumuraCenter for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan.
Akira MurakamiDepartment of Ophthalmology, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Juntendo University · JPJuntendo University Hospital · JPThe University of Tokyo · JPYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of anti-CD80/86 antibodies in a murine high-risk corneal transplantation rejection model. A mixed lymphocyte reaction (MLR) assay was conducted with anti-CD80/86 antibodies. Inflammatory cytokine levels in the culture supernatant were measured using an enzyme-linked immunosorbent assay. Interferon (IFN)-γ-producing CD4

Indexed as

Corneal TransplantationGraft SurvivalAnimalsGraft RejectionMiceMice, Inbred BALB CMice, Inbred C57BL

Identifiers

PMID35318419
PMCPMC8941080
OpenAlexW4220828262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.