ArticleScientific reports2022
Er:YAG laser-induced cavitation can activate irrigation for the removal of intraradicular biofilm.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Postoperative pain in primary root canal treatments after Er: YAG laser-activated irrigation: a systematic review and meta-analysis.Lasers in medical science · 2025Pooled it
- Comparative bubble dynamics of plasma-mediated Nd: YAG laser-induced optical breakdown and thermally driven Er: YAG laser-activated irrigation in water.Lasers in medical science · 2026Article
- Effectiveness and safety of water laser-assisted endodontic-periodontal therapy: A retrospective controlled study.The Journal of international medical research · 2026Article
- Can lasers help reduce post-root-canal pain more than ultrasonics?Evidence-based dentistry · 2026Article
- Impact of sodium hypochlorite on the dissolution of soft tissue with photon-initiated photoacoustic streaming (PIPS) activation.BMC oral health · 2025Article
- Evaluation of antibacterial efficacy of laser-assisted and passive ultrasonic irrigation methods in disinfection of post space and effects on bond strength of glass fiber posts to radicular dentin.Lasers in medical science · 2025Article
- Antibacterial Effects of Er:YAG Laser Irradiation onLife (Basel, Switzerland) · 2025Article
- Biomechanical Behaviors of Molars Restored with Endocrowns Composed of Different Materials.Materials (Basel, Switzerland) · 2025Article
- Exploratory study on the application of laser-induced cavitation bubble in the treatment of fallopian tube obstruction.PloS one · 2025Article
- Laser Applications in Regenerative Endodontics: A Review.Journal of lasers in medical sciences · 2024Review
- Article
- The Evaluation of SWEEPS Plus Antimicrobial Photodynamic Therapy with Indocyanine Green in EliminatingBiomedicines · 2023Article
- Determination of a Representative and 3D-Printable Root Canal Geometry for Endodontic Investigations and Pre-Clinical Endodontic Training-An Ex Vivo Study.Dentistry journal · 2023Article
- Current Applications and Future Directions of Lasers in Endodontics: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Knowledge, awareness, and perception on root canal treatment among South Indian population - A survey.Journal of advanced pharmaceutical technology & research · 2022Article
- Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the biofilm removal effects of laser activated irrigation (LAI) using a pig model, focusing on the impact of the fiber tip position, and used a high-speed camera to observe the occurrence and positioning of the cavitation associated with laser irradiation. A total of 16 roots of deciduous mandibular second premolars from 4 pigs were used. After a pulpectomy, the canals were left open for 2 weeks and sealed for 4 weeks to induce intraradicular biofilm. Root canal irrigation was then performed with Er:YAG laser activation. The fiber tip was inserted at two different positions, i.e., into the root canal in the intracanal LAI group and into the pulp chamber in the coronal LAI group. Intracanal needle irrigation with saline or 5% NaOCl was utilized in the positive control and conventional needle irrigation (CNI) groups. SEM and qPCR were carried out to evaluate treatment efficacy. Statistical analysis was performed using ANOVA and a Tukey-Kramer post-hoc test for qPCR and with a Steel-Dwass test to compare the SEM scores, with α = 0.05. A high-speed camera was used to observe the generation of cavitation bubbles and the movement of the induced bubbles after laser irradiation. The intracanal and coronal LAI groups showed significantly lower amounts of bacteria than either the positive control or CNI groups. There was no significant difference found between the intracanal and coronal LAI groups. SEM images revealed opened dentinal tubules with the destruction of biofilm in both LAI groups. High-speed camera images demonstrated cavitation bubble production inside the root canal after a single pulse irradiation pulse. The generated bubbles moved throughout the entire internal multi-rooted tooth space. Coronal LAI can generate cavitation in the root canal with a simply placed fiber inside the pulp chamber, leading to effective biofilm removal. This method could thus contribute to the future development of endodontic treatments for refractory apical periodontitis caused by intraradicular biofilm.
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