ArticleScientific reports2022
EEG functional connectivity is sensitive for nitrogen narcosis at 608 kPa.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Electroencephalographic (EEG) changes accompanying normal breathing of concentrated oxygen (hyperoxic ventilation) by healthy adults: a systematic review.Diving and hyperbaric medicine · 2025Pooled it
- Cognitive risk during underwater exposure: from environmental stressors to assessment and context-aware monitoring.Frontiers in physiology · 2026Review
- Effect of hyperbaric exposure on cognitive performance: an investigation conducting numerical Stroop tasks during a simulated 440 m sea water saturation diving.Journal of physiological anthropology · 2024Article
- Drinker driver flyer diver.Diving and hyperbaric medicine · 2024Article
- Comparing the EMMA capnograph with sidestream capnography and arterial carbon dioxide pressure at 284 kPa.Diving and hyperbaric medicine · 2023Article
- Does hyperbaric oxygen cause narcosis or hyperexcitability? A quantitative EEG analysis.Physiological reports · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Divers commonly breathe air, containing nitrogen. Nitrogen under hyperbaric conditions is a narcotic gas. In dives beyond a notional threshold of 30 m depth (405 kPa) this can cause cognitive impairment, culminating in accidents due to poor decision making. Helium is known to have no narcotic effect. This study explored potential approaches to developing an electroencephalogram (EEG) functional connectivity metric to measure narcosis produced by nitrogen at hyperbaric pressures. Twelve human participants (five female) breathed air and heliox (in random order) at 284 and 608 kPa while recording 32-channel EEG and psychometric function. The degree of spatial functional connectivity, estimated using mutual information, was summarized with global efficiency. Air-breathing at 608 kPa (experienced as mild narcosis) caused a 35% increase in global efficiency compared to surface air-breathing (mean increase = 0.17, 95% CI [0.09-0.25], p = 0.001). Air-breathing at 284 kPa trended in a similar direction. Functional connectivity was modestly associated with psychometric impairment (mixed-effects model r
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.