Evidence map›Paper›PMID 35318386›Full record

ArticleScientific reports2022

Determinants of misuse of antibiotics among parents of children attending clinics in regional referral hospitals in Tanzania.

Ritah F Mutagonda, Alphonce I Marealle, Lilian Nkinda, Upendo Kibwana, Betty A Maganda, Belinda J Njiro, Harrieth P Ndumwa, Manase Kilonzi, Wigilya P Mikomangwa, Hamu J Mlyuka and 12 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07393308 (Enhancing the Optimization of Empirical Antibiotic Therapy), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07393308 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Enhancing the Optimization of Empirical Antibiotic Therapy: Development and Implementation of Mobile Antibiograms in Tertiary Hospitals in Tanzania

TypeinterventionalSponsorMuhimbili University of Health and Allied SciencesRan2026 to 2028Enrolled300ConditionsAntimicrobial Prescribing Practices, Antimicrobial Resistance (AMR)ArmsMobile antibiogram application, standard of care
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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  15. Pattern of antibiotic use among children caregivers: a cross-sectional study.The Journal of the Egyptian Public Health Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 3 countries.

Ritah F Mutagonda *School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Alphonce I MarealleSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Lilian Nkinda *School of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Upendo Kibwana *School of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Betty A MagandaSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Belinda J NjiroSchool of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Harrieth P NdumwaSchool of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Manase KilonziSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Wigilya P MikomangwaSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Hamu J MlyukaSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Fatuma F FelixSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
David T MyembaSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Dorkasi L MwakawangaSchool of Nursing, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Godfrey SambayiSchool of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Peter P KunambiSchool of Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Pacifique NdayishimiyeDepartment of Pharmacy, University of Rwanda, P.O. Box 4285, Kigali, Rwanda. pacimiye@gmail.com.
Nathanael SiriliSchool of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Rashid MfaumeRegional Administrative Secretary, Dar Es Salaam Region, P.O. Box 5429, Dar es Salaam, Tanzania.
Arapha NshauPharmacy Council, Ministry of Health, Community Development, Gender, Elderly and Children, P.O. Box 31818, Dar es Salaam, Tanzania.
Elevanie NyankeshaUnited Nations Children's Fund, New York Head Quarter, 3 United Nations Plaza, New York, NY, 10017, USA.
Robert ScherpbierUnited Nations Children's Fund, Bâtiment BIT, Route des Morillons 4, 1211, Geneva 22, Switzerland.
George M Bwire *School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Muhimbili University of Health and Allied Sciences · TZMinistry of Health, Community Development, Gender, Elderly and Children · TZUnited Nations Children's Fund · USUniversity of Rwanda · RW

Funding

Wellcome TrustWellcome Trust 216341/Z/19/Z
6 · The paper itself

Abstract

Parents are the important implementers on appropriate/inappropriate use of antibiotics, especially in the pediatric population. Limited studies have associated poor knowledge, attitude, and practice (KAP) among parents with antibiotics misuse. Therefore, this study was conducted to determine the parents' KAP and factors associated with inappropriate use of antibiotics among Tanzanian children. A hospital-based cross-sectional study was conducted in 14 regional referral hospitals (RRHs) in Tanzania between June and September 2020. KAP was estimated using a Likert scale, whereas KAP factors were determined using logistic regression models. A total of 2802 parents were enrolled in the study. The median age (interquartile range) of parents was 30.0 (25-36) years where 82.4% (n = 2305) were female parents. The majority of the parents had primary education, 56.1% (n = 1567). Of 2802 parents, only 10.9% (n = 298) had good knowledge about antibiotics, 16.4% (n = 455) had positive attitude whereas 82.0% (n = 2275) had poor practice on the appropriate use of antibiotics. Parents' education level, i.e., having a university degree (aOR: 3.27 95% CI 1.62-6.63, p = 0.001), good knowledge (aOR: 1.70, 95% CI 1.19-2.23, p = 0.003) and positive attitudes (aOR: 5.56, 95% CI 4.09-7.56, p < 0.001) were significantly associated with the appropriate use of antibiotics in children. Most parents had poor knowledge, negative attitude, and poor practice towards antibiotics use in children. Parents' education level, employment status, knowledge on antibiotic use, and good attitude contributed to the appropriate use of antibiotics in children attending clinics at RRHs.

Indexed as

Anti-Bacterial AgentsHealth Knowledge, Attitudes, PracticeAdultChildCross-Sectional StudiesFemaleHospitalsHumansMaleParentsReferral and ConsultationSurveys and QuestionnairesTanzaniaAnti-Bacterial Agents

Identifiers

PMID35318386
PMCPMC8941073
OpenAlexW4220746533

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.