Evidence map›Paper›PMID 35318369›Full record

ArticleScientific reports2022

Gabrb3 endothelial cell-specific knockout mice display abnormal blood flow, hypertension, and behavioral dysfunction.

Anass Agrud, Sivan Subburaju, Pranay Goel, Jun Ren, Ashwin Srinivasan Kumar, Barbara J Caldarone, Wangde Dai, Jesus Chavez, Dai Fukumura, Rakesh K Jain and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. The Molecular Heterogeneity of Store-Operated CaInternational journal of molecular sciences · 2023
    Review
  8. Review
  9. GABACells · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Anass Agrud *Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Sivan Subburaju *Angiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Pranay GoelAngiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA.
Jun RenEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Ashwin Srinivasan KumarEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Barbara J CaldaroneMouse Behavior Core, Department of Genetics, Harvard Medical School, Boston, MA, USA.
Wangde DaiHuntington Medical Research Institutes, Pasadena, CA, USA.
Jesus ChavezHuntington Medical Research Institutes, Pasadena, CA, USA.
Dai FukumuraEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Rakesh K JainEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Robert A KlonerHuntington Medical Research Institutes, Pasadena, CA, USA.
Anju VasudevanAngiogenesis and Brain Development Laboratory, Huntington Medical Research Institutes (HMRI), 686 S Fair Oaks Avenue, Pasadena, CA, 91105, USA. anju.vasudevan@hmri.org.
Huntington Medical Research Institutes · USHarvard University · USMassachusetts General Hospital · USUniversity of Southern California · USMassachusetts Institute of Technology · US

Funding

Dissecting Pediatric Brain Tumor Microenvironment to Improve TreatmentR35CA197743 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2015 to 2020
$5.7M
Novel Developmental Pathways Underlying Psychiatric DisordersR01MH110438 · NIMH · MCLEAN HOSPITAL · PI Anju Vasudevan · 2016 to 2026
$4.7M
Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolismR01CA259253 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K., VANDER HEIDEN, MATTHEW G. · 2021 to 2025
$2.3M
Reengineering obesity-induced abnormal microenvironment to improve PDAC treatmentR01CA208205 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FUKUMURA, DAI, JAIN, RAKESH K. · 2017 to 2020
$2.2M
Reprogramming the Tumor Microenvironment to Improve Immunotherapy of Glioblastoma by Co-Targeting VEGF and Ang2R01NS118929 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI FUKUMURA, DAI · 2021 to 2025
$2.0M
Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastomaR01CA269672 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Rakesh K. Jain · 2022 to 2026
$1.9M
Novel Autonomous Roles of CNS AngiogenesisR01NS100808 · NINDS · MCLEAN HOSPITAL · PI VASUDEVAN, ANJU · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA208205NCI NIH HHS R01 CA259253NCI NIH HHS R01 CA269672NCI NIH HHS R35 CA197743NIMH NIH HHS R01 MH110438NINDS NIH HHS R01 NS100808NINDS NIH HHS R01 NS118929
6 · The paper itself

Abstract

Our recent studies uncovered a novel GABA signaling pathway in embryonic forebrain endothelial cells that works independently from neuronal GABA signaling and revealed that disruptions in endothelial GABA

Indexed as

HypertensionReceptors, GABA-AAnimalsEndothelial Cellsgamma-Aminobutyric AcidMiceMice, KnockoutGabrb3 protein, mousegamma-Aminobutyric AcidReceptors, GABA-A

Identifiers

PMID35318369
PMCPMC8941104
OpenAlexW4220695025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.