Evidence map›Paper›PMID 35318366›Full record

ArticleScientific reports2022

Clr-f expression regulates kidney immune and metabolic homeostasis.

Haggag S Zein, Elias Abou-Samra, Michal Scur, Alex Gutsol, Clayton W Hall, Bishal Dasgupta, Lara Gharibeh, Turki Abujamel, Daniel Medina-Luna, Gayani S Gamage and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Haggag S Zein *Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Elias Abou-Samra *Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
Michal ScurDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Alex GutsolDivision of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Clayton W HallDepartment of Pathology and Molecular Medicine, Division of Medical Microbiology, McMaster University, Hamilton, ON, Canada.
Bishal DasguptaDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Lara GharibehMolecular Genetics and Cardiac Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
Turki AbujamelVaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Daniel Medina-LunaDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Gayani S GamageDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Tessa J PelinoDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Mona NemerDepartment of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
Mir Munir A RahimDepartment of Biomedical Sciences, University of Windsor, Windsor, ON, Canada.
Alexander SteinleInstitute for Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany.
Brendon D ParsonsDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada. brendonp@dal.ca.
Andrew P MakrigiannisDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada. andrew.makrigiannis@dal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The C-type lectin-related protein, Clr-f, encoded by Clec2h in the mouse NK gene complex (NKC), is a member of a family of immune regulatory lectins that guide immune responses at distinct tissues of the body. Clr-f is highly expressed in the kidney; however, its activity in this organ is unknown. To assess the requirement for Clr-f in kidney health and function, we generated a Clr-f-deficient mouse (Clr-f

Indexed as

Killer Cells, NaturalLectins, C-TypeAnimalsHomeostasisKidneyLipidsMiceMice, Inbred C57BLNK Cell Lectin-Like Receptor Subfamily BLectins, C-TypeLipidsNK Cell Lectin-Like Receptor Subfamily B

Identifiers

PMID35318366
PMCPMC8940912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.