ArticleNature communications2022
Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of research on augmentative and alternative communication brain-computer interface systems for individuals with disabilities.Frontiers in human neuroscience · 2022Pooled it
- Real-time detection of spoken speech from unlabeled ECoG signals: a pilot study with an ALS participant.Journal of neural engineering · 2025Trial
- The challenge of controlling an auditory BCI in the case of severe motor disability.Journal of neuroengineering and rehabilitation · 2024Trial
- Interim Safety Profile From the Feasibility Study of the BrainGate Neural Interface System.Neurology · 2023Trial
- Article
- Ethical challenges in treatment-goal transitions in invasively ventilated ALS: a case-based topical review.Neurological research and practice · 2026Review
- [Research on auditory neurofeedback technology and its multi-disciplinary applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Multi-Level Perception Systems in Fusion of Lifeforms: Classification, Challenges and Future Conceptions.Sensors (Basel, Switzerland) · 2026Review
- Brain-aligning of semantic vectors improves neural decoding of visual stimuli.Communications biology · 2026Article
- Individualized brain-computer interface for people with disabilities: a review.Frontiers in human neuroscience · 2026Review
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- Multidisciplinary rehabilitation and eye tracker-assisted communication in locked-in syndrome: a case report and literature review.Frontiers in human neuroscience · 2026Article
- Clinical evaluation of communication brain computer interfaces in amyotrophic lateral sclerosis: a landscape analysis.Frontiers in human neuroscience · 2026Article
- Brain-computer interfaces: a new horizon in communication for locked-in syndrome.Annals of medicine and surgery (2012) · 2025Article
- "Your Thoughts are (were) Free!": Brain-Computer-Interfaces, Neurofeedback, Detection of Deception, and the Future of Mind-Reading.Applied psychophysiology and biofeedback · 2025Review
- Towards Predictive Communication: The Fusion of Large Language Models and Brain-Computer Interface.Sensors (Basel, Switzerland) · 2025Review
- Learning to operate an imagined speech Brain-Computer Interface involves the spatial and frequency tuning of neural activity.Communications biology · 2025Article
- Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Review
- Toward brain-computer interface speller with movement-related cortical potentials as control signals.Frontiers in human neuroscience · 2025Article
- Acoustic Inspired Brain-to-Sentence Decoder for Logosyllabic Language.Cyborg and bionic systems (Washington, D.C.) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with amyotrophic lateral sclerosis (ALS) can lose all muscle-based routes of communication as motor neuron degeneration progresses, and ultimately, they may be left without any means of communication. While others have evaluated communication in people with remaining muscle control, to the best of our knowledge, it is not known whether neural-based communication remains possible in a completely locked-in state. Here, we implanted two 64 microelectrode arrays in the supplementary and primary motor cortex of a patient in a completely locked-in state with ALS. The patient modulated neural firing rates based on auditory feedback and he used this strategy to select letters one at a time to form words and phrases to communicate his needs and experiences. This case study provides evidence that brain-based volitional communication is possible even in a completely locked-in state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.