Evidence map›Paper›PMID 35318191›Full record

ArticleBMJ open gastroenterology2022

Predicting 1-year mortality among patients with decompensated cirrhosis: results of a multicentre evaluation of the Bristol Prognostic Score.

Sarah Pauline Bowers, Kathleen Clare, Louise Hagerty, Kirsty McColl, Eva Smith, Alana Brown-Kerr, Asma Ahmed, Fiona Finlay, John F Dillon, Stephen Barclay

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMJ open gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sarah Pauline BowersNHS Tayside, Dundee, UK sarah.bowers3@nhs.scot.ORCID http://orcid.org/0000-0003-0722-8318
Kathleen ClareNHS Forth Valley, Stirling, UK.
Louise HagertyGlasgow Royal Infirmary, Glasgow, UK.
Kirsty McCollNHS Forth Valley, Stirling, UK.
Eva SmithNHS Tayside, Dundee, UK.
Alana Brown-KerrNHS Tayside, Dundee, UK.
Asma AhmedNHS Forth Valley, Stirling, UK.
Fiona FinlayQueen Elizabeth University Hospital, Glasgow, UK.
John F DillonNHS Tayside, Dundee, UK.
Stephen BarclayGlasgow Royal Infirmary, Glasgow, UK.
NHS Tayside · GBNHS Forth Valley · GBGlasgow Royal Infirmary · GBQueen Elizabeth University Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChronic liver disease continues to be a significant cause of morbidity and mortality yet remains challenging to prognosticate. This has been one of the barriers to implementing palliative care, particularly at an early stage. The Bristol Prognostic Score (BPS) was developed to identify patients with life expectancy less than 12 months and to act as a trigger for referral to palliative care services. This study retrospectively evaluated the BPS in a cohort of patients admitted to three Scottish hospitals.

methodRoutinely collated healthcare data were used to obtain demographics, BPS and analyse 1-year mortality for patients with decompensated liver disease admitted to three gastroenterology units over two 90-day periods. Statistical analysis was undertaken to assess performance of BPS in predicting mortality.

results276 patients were included in the final analysis. Participants tended to be late middle-aged men, socioeconomically deprived and have alcohol-related liver disease. A similar proportion was BPS+ve (>3) in this study compared with the original Bristol cohort though had more hospital admissions, higher ongoing alcohol use and poorer performance status. BPS performed poorer in this non-Bristol group with sensitivity 54.9% (72.2% in original study), specificity 58% (83.8%) and positive predictive value (PPV) 43.4% (81.3%).

conclusionBPS was unable to accurately predict mortality in this Scottish cohort. This highlights the ongoing challenge of prognostication in patients with chronic liver disease, furthering the call for more work in this field.

Indexed as

HospitalizationLiver CirrhosisHospital MortalityHumansMaleMiddle AgedPrognosisRetrospective Studieschronic liver diseaseliverliver cirrhosis

Identifiers

PMID35318191
PMCPMC8943768
OpenAlexW4220704520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.