Evidence map›Paper›PMID 35318050›Full record

ArticleThe Science of the total environment2022

Ambient ozone effects on respiratory outcomes among smokers modified by neighborhood poverty: An analysis of SPIROMICS AIR.

Daniel C Belz, Han Woo, Nirupama Putcha, Laura M Paulin, Kirsten Koehler, Ashraf Fawzy, Neil E Alexis, R Graham Barr, Alejandro P Comellas, Christopher B Cooper and 16 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Science of the total environment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. An Issue of Caliber: The Airway Tree and Air Pollution Susceptibility.American journal of respiratory and critical care medicine · 2024
    Article
  4. Article
  5. Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 15 institutions in 1 country.

Daniel C BelzDepartment of Medicine, Johns Hopkins University, 1830 E. Monument, 5th Floor, Baltimore, MD 21205, USA. Electronic address: Dbelz2@jhmi.edu.
Han WooDepartment of Medicine, Johns Hopkins University, 1830 E. Monument, 5th Floor, Baltimore, MD 21205, USA. Electronic address: Hwoo4@jhu.edu.
Nirupama PutchaDepartment of Medicine, Johns Hopkins University, 1830 E. Monument, 5th Floor, Baltimore, MD 21205, USA. Electronic address: Nputcha1@jhmi.edu.
Laura M PaulinDartmouth-Hitchcock Medical Center/Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Pulmonary 5C Ste, Lebanon, NH 03756, USA. Electronic address: laura.m.paulin@hitchcock.org.
Kirsten KoehlerJohns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: kkoehle1@jhu.edu.
Ashraf FawzyDepartment of Medicine, Johns Hopkins University, 1830 E. Monument, 5th Floor, Baltimore, MD 21205, USA. Electronic address: Afawzy1@jhmi.edu.
Neil E AlexisUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: neil_alexis@med.unc.edu.
R Graham BarrColumbia University Medical Center, 630 W. 168th St., New York, NY 10032, USA. Electronic address: rgb9@cumc.columbia.edu.
Alejandro P ComellasUniversity of Iowa Department of Internal Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. Electronic address: alejandro-comellas@uiowa.edu.
Christopher B CooperUniversity of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: ccooper@mednet.ucla.edu.
David CouperUniversity of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: david_couper@unc.edu.
Mark DransfieldUniversity of Alabama, Birmingham, 1720 2nd Ave South, Birmingham, AL 35294, USA. Electronic address: mdransfield@uabmc.edu.
Amanda J GassettUniversity of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: agassett@uw.edu.
MeiLan HanUniversity of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA. Electronic address: mrking@med.umich.edu.
Eric A HoffmanUniversity of Iowa Department of Internal Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA. Electronic address: eric-hoffman@uiowa.edu.
Richard E KannerUniversity of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA. Electronic address: richard.kanner@hsc.utah.edu.
Jerry A KrishnanUniversity of Illinois at Chicago, 1853 West Polk Street, Chicago, IL 60612, USA. Electronic address: jakris@uic.edu.
Fernando J MartinezWeill Cornell Medicine, 300 York Ave, New York, NY 10065, USA. Electronic address: fjm2003@med.cornell.edu.
Robert PaineUniversity of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA. Electronic address: robert.paine@hsc.utah.edu.
Roger D PengJohns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: rdpeng@jhu.edu.
Stephen PetersWake Forest University, 475 Vine St, Winston-Salem, NC 27101, USA. Electronic address: sppeters@wakehealth.edu.
Cheryl S PirozziUniversity of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA. Electronic address: cheryl.pirozzi@hsc.utah.edu.
Prescott G WoodruffUniversity of California, San Francisco, 513 Parnassus Ave, HSE, San Francisco, CA 94143, USA. Electronic address: prescott.woodruff@ucsf.edu.
Joel D KaufmanUniversity of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: joelk@uw.edu.
Nadia N HanselDepartment of Medicine, Johns Hopkins University, 1830 E. Monument, 5th Floor, Baltimore, MD 21205, USA. Electronic address: Nhansel1@jhmi.edu.
SPIROMICS Investigators
Johns Hopkins University · USUniversity of Utah · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USColumbia University Irving Medical Center · USDartmouth–Hitchcock Medical Center · USSeattle Pacific University · USUniversity of Alabama at Birmingham · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of Michigan–Ann Arbor · USUniversity of Washington · USWake Forest University · USWeill Cornell Medicine · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
SPIROMICS - Air Pollution StudyR01ES023500 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N, KAUFMAN, JOEL DANIEL · 2014 to 2018
$3.2M
Indoor Air Pollution, Mucociliary Clearance, and Mucus Properties in COPDK23ES025781 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI PAULIN, LAURA MARIE · 2015 to 2019
$832k
The Effect of Phthalates on COPD MorbidityF32HL154516 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BELZ, DANIEL CARPENTER · 2020 to 2021
$111k
NHLBI NIH HHS F32 HL154516NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS L30 HL159722NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIEHS NIH HHS K23 ES025781NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES023500
6 · The paper itself

Abstract

backgroundNeighborhood poverty has been associated with poor health outcomes. Previous studies have also identified adverse respiratory effects of long-term ambient ozone. Factors associated with neighborhood poverty may accentuate the adverse impact of ozone on respiratory health.

objectivesTo evaluate whether neighborhood poverty modifies the association between ambient ozone exposure and respiratory morbidity including symptoms, exacerbation risk, and radiologic parameters, among participants of the SPIROMICS AIR cohort study.

methodsSpatiotemporal models incorporating cohort-specific monitoring estimated 10-year average outdoor ozone concentrations at participants' homes. Adjusted regression models were used to determine the association of ozone exposure with respiratory outcomes, accounting for demographic factors, education, individual income, body mass index (BMI), and study site. Neighborhood poverty rate was defined by percentage of families living below federal poverty level per census tract. Interaction terms for neighborhood poverty rate with ozone were included in covariate-adjusted models to evaluate for effect modification.

results1874 participants were included in the analysis, with mean (± SD) age 64 (± 8.8) years and FEV

conclusionIndividuals with COPD in high poverty neighborhoods have higher susceptibility to adverse respiratory effects of ambient ozone exposure, after adjusting for individual factors. These findings highlight the interaction between exposures associated with poverty and their effect on respiratory health.

Indexed as

Air PollutantsAir PollutionOzonePulmonary Disease, Chronic ObstructiveCohort StudiesEnvironmental ExposureHumansMiddle AgedPovertySmokersAir PollutantsOzoneAir pollutionChronic obstructive pulmonary diseaseOzonePoverty areasSocioeconomic factors

Identifiers

PMID35318050
PMCPMC9117415
OpenAlexW4220950840

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.