Evidence map›Paper›PMID 35317851›Full record

ArticleBioelectronic medicine2022

Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder.

Hui Zhong, Emilie Liu, Priya Kohli, Laura Perez, V Reggie Edgerton, David Ginsberg, Parag Gad, Evgeniy Kreydin

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03753750 (Evaluation of Noninvasive Spinal Cord Stimulation for Neurogenic and Idiopathic Overactive Bladder), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03753750 nawithdrawnnot on this map

Evaluation of Noninvasive Spinal Cord Stimulation for Neurogenic and Idiopathic Overactive Bladder

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2020 to 2022Enrolled0ConditionsOveractive Bladder, Incontinence, Urge, Neurogenic BladderArmsNoninvasive spinal cord stimulation
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Hui ZhongDepartment of Neurobiology, University of California, Los Angeles, CA, 90095, USA.
Emilie LiuDepartment of Neurobiology, University of California, Los Angeles, CA, 90095, USA.
Priya KohliRancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA.
Laura PerezRancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA.
V Reggie EdgertonDepartment of Neurobiology, University of California, Los Angeles, CA, 90095, USA.
David GinsbergRancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA.
Parag GadDepartment of Neurobiology, University of California, Los Angeles, CA, 90095, USA. parag@spinex.co.
Evgeniy KreydinRancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA.
University of Southern California · USRancho Research Institute · USInstitut Guttmann · ESRancho Los Amigos National Rehabilitation Center · USUniversity of California, Los Angeles · US

Funding

Transformation of Dormant Spinal Networks to Mitigate Symptoms of Neurogenic BladderR44DK129164 · NIDDK · SPINEX, INC. · PI GAD, PARAG · 2021 to 2022
$1.9M
NIDDK NIH HHS R44 DK129164NIDDK NIH HHS R44DK129164
6 · The paper itself

Abstract

backgroundOveractive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures such as lifestyle modification and pelvic floor physical therapy are the first line of treatment for overactive bladder. Patients who fail these may go on to take medications, undergo neuromodulation or receive injection of botulinum toxin into the bladder wall. While effective, medications have side effects and suffer from poor adherence. Neuromodulation and botulinum toxin injection are also effective but are invasive and not acceptable to some patients.

methodsWe have developed a novel transcutaneous spinal cord neuromodulator (SCONE™

resultsAll patients reported statistically significant clinical improvement in multiple symptoms of overactive bladder, such as urinary urgency, frequency and urge incontinence. In addition, patients reported significant symptomatic improvements as captured by validated clinical surveys.

conclusionSCONE™ therapy represents the first of its kind therapy to treat symptoms of urgency, frequency and urge urinary incontinence in patients with OAB.

trial registrationThe study was listed on clinicaltrials.gov ( NCT03753750 ).

Indexed as

Lower urinary tractNon-invasive spinal cord stimulationOveractive bladderUrge urinary incontinenceUrodynamics

Identifiers

PMID35317851
PMCPMC8941742
OpenAlexW4220734911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.