Evidence map›Paper›PMID 35317741›Full record

ArticleBMC pregnancy and childbirth2022

Association of surfactant protein D gene polymorphism with susceptibility to gestational diabetes mellitus: a case-control study.

Jingwei Xu, Yi Chen, Liangfang Tang, Xinyuan Teng, Lin Feng, Ligui Jin, Guirong Wang, Liquan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Collectins and Ficolins.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jingwei XuSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
Yi ChenThe First People's Hospital of Wenling, Wenling, 317500, Zhejiang, China.
Liangfang TangSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
Xinyuan TengSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
Lin FengSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
Ligui JinSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
Guirong WangDepartment of Surgery, SUNY Upstate Medical University, UH Room 8715, 750 E Adams St, Syracuse, NY, 13210, USA. wangg@upstate.edu.
Liquan WangSchool of Medicine, The Second Affiliated Hospital, Zhejiang University, Hangzhou, 310009, Zhejiang, China. wangliquan@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNSUNY Upstate Medical University · USThe First People's Hospital of Wenling · CN

Funding

Mechanisms of differential susceptibility of human SP-B genetic variants to pneumonia and lung injuryR01HL136706 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI WANG, GUIRONG · 2017 to 2020
$1.6M
Natural Science Foundation of Zhejiang Province No. LY19H040014NHLBI NIH HHS R01 HL136706
6 · The paper itself

Abstract

backgroundSurfactant protein D (SP-D) is a critical component of the innate immune system intrinsically linked to energy metabolism. However, the relationship of SP-D gene polymorphisms and gestational diabetes mellitus (GDM) remains unclear. In this study, we analyzed SP-D gene polymorphisms in GDM patients and nondiabetic controls and then determined the association of SP-D gene polymorphisms with GDM.

methodsWe examined a common genetic polymorphism located in the SP-D coding region (rs721917, Met31Thr) in GDM patients (n = 147) and healthy pregnant controls (n = 97) by using a cleaved amplification polymorphism sequence-tagged sites (PCR-RFLP) technique. The level of SP-D protein in the serum of GDM patients and nondiabetic controls was determined by ELISA. The gene and allele frequencies of SP-D and their association with GDM as well as SP-D protein levels were analyzed and expressed as odds ratios (ORs) with 95% confidence intervals (95% CIs).

resultsWe found that there was a significant association of the SP-D polymorphism (rs721917) with GDM. The SP-D (T/T) genotype was found in 11.6% and 21.6% of GDM patients and matched healthy controls, respectively (odds ratio, 0.473; 95% confidence interval, 0.235-0.952; P = 0.033), indicating that women with the (T/T) genotype had a lower prevalence of GDM (OR = 0.473). Women with the T/C genotype showed an increased risk of GDM (odds ratio, 2.440; 95% confidence interval, 1.162-5.123; P = 0.017). We did not observe corrections between glucose homeostasis markers and SP-D genotypes in women with GDM. Furthermore, serum SP-D levels were higher in GDM patients than in matched healthy controls.

conclusionsThis study found the first evidence that an SP-D gene polymorphism (rs721917) was associated with GDM, which may provide the basis for further study on how SP-D plays a regulatory role in GDM.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAsian PeopleCase-Control StudiesDiabetes, GestationalFemaleHumansPregnancyPulmonary Surfactant-Associated Protein DYoung AdultPulmonary Surfactant-Associated Protein DAlleleGestational diabetes mellitus (GDM)PolymorphismsSP-D

Identifiers

PMID35317741
PMCPMC8939171
OpenAlexW4220658864

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.