Evidence map›Paper›PMID 35317717›Full record

ArticleEmerging microbes & infections2022

Pandemic influenza A (H1N1) virus causes abortive infection of primary human T cells.

Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Advances in Single-Cell Sequencing for Infectious Diseases: Progress and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Jiapei YuDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People's Republic of China.
Hui LiDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Ju JiaDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Zhisheng HuangDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Shuai LiuDepartment of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
Ying ZhengDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Shengrui MuDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Xiaoyan DengDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People's Republic of China.
Xiaohui ZouDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Yeming WangDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Xiao ShangDepartment of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, People's Republic of China.
Dan CuiDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Lixue HuangDepartment of Pulmonary and Critical Care Medicine, Centre of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Xiaoxuan FengDepartment of Respiratory Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
William J LiuNHC Key Laboratory of Biosafety, Chinese Centre for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing, People's Republic of China.
Bin CaoTsinghua University-Peking University Joint Centre for Life Sciences, Tsinghua University, Beijing, People's Republic of China.ORCID 0000-0001-6991-0350
Capital University · USPeking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChina-Japan Friendship Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNHarbin Medical University · CNNational Institute for Viral Disease Control and Prevention · CNShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus still represents a noticeable epidemic risk to international public health at present, despite the extensive use of vaccines and anti-viral drugs. In the fight against pathogens, the immune defence lines consisting of diverse lymphocytes are indispensable for humans. However, the role of virus infection of lymphocytes and subsequent abnormal immune cell death remains to be explored. Different T cell subpopulations have distinct characterizations and functions, and we reveal the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesOrthomyxoviridae InfectionsCD8-Positive T-LymphocytesHumansInfluenza Vaccinesabortive infectionInfluenza A virusprimary T cellssingle-cell sequencingvirus-host interactions

Identifiers

PMID35317717
PMCPMC9045768
OpenAlexW4220919258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.