Evidence map›Paper›PMID 35317662›Full record

SynthesisJournal of cutaneous medicine and surgery

A Systematic Review Characterizing Psoriatic Arthritis Onset and Exacerbation in Patients Receiving Biologic Therapy.

Muskaan Sachdeva, Abrahim Abduelmula, Asfandyar Mufti, Jorge R Georgakopoulos, Yuliya Lytvyn, Jensen Yeung

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cutaneous medicine and surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muskaan Sachdeva7938 Temerty Faculty of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-2252-5663
Abrahim Abduelmula70384 Faculty of Medicine, Western University, London, ON, Canada.
Asfandyar MuftiDivision of Dermatology, Department of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-3514-9513
Jorge R GeorgakopoulosDivision of Dermatology, Department of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0000-0002-6844-2724
Yuliya Lytvyn7938 Temerty Faculty of Medicine, University of Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1805-9994
Jensen YeungDivision of Dermatology, Department of Medicine, University of Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile biologic therapies revolutionized treatment of immune-mediated inflammatory diseases (IMIDs), some adverse effects have been noted. This includes the development and exacerbation of PsA in patients on biologic agents, however the outcomes were not extensively explored.

objectiveTo perform a systematic review to characterize the outcomes of PsA onset or exacerbation secondary to biologic use.

methodsMEDLINE and EMBASE search conducted on March 23, 2021 resulted in 18 studies comprised of 64 patients.

resultsOf the 64 patients, 57 (89.1%) experienced new-onset PsA and 7 (10.9%) experienced exacerbation of preexisting PsA following exposure to a biologic; most commonly a TNF-α inhibitor (42.2%,

conclusionAlthough we characterized outcomes of PsA induction and exacerbation secondary to biologic use, large-scale studies are required.

Indexed as

Antirheumatic AgentsArthritis, PsoriaticBiological ProductsBiological TherapyHumansTumor Necrosis Factor-alphaAntirheumatic AgentsBiological ProductsTumor Necrosis Factor-alphabiologicsparadoxical reactionpsoriatic arthritissystematic review

Identifiers

PMID35317662
PMCPMC9361424

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.