Evidence map›Paper›PMID 35317619›Full record

ArticleJournal of clinical microbiology2022

Evaluation of the Hologic Aptima Combo 2 Assay for Detection of Neisseria gonorrhoeae from Joint Fluid Specimens.

David C Alexander, Robert M Taylor, Irene Martin, Heather Adam, Philippe Lagacé-Wiens, Peter Pieroni, James A Karlowsky, Paul Van Caeseele

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

David C AlexanderCadham Provincial Laboratory, Winnipeg, Manitoba, Canada.
Robert M TaylorMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Irene MartinPublic Health Agency of Canada, National Microbiology Laboratory, Streptococcus and STI Unit, Winnipeg, Manitoba, Canada.ORCID 0000-0002-3941-5583
Heather AdamMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Philippe Lagacé-WiensMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID 0000-0002-5826-2869
Peter PieroniShared Health, Diagnostic Services, Manitoba, Canada.
James A KarlowskyMax Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Paul Van CaeseeleCadham Provincial Laboratory, Winnipeg, Manitoba, Canada.
Shared Health · CAUniversity of Manitoba · CAPublic Health Agency of Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gonorrhea is a sexually transmitted bacterial infection caused by Neisseria gonorrhoeae. Nucleic acid amplification testing is the preferred method for routine diagnosis of gonorrhea from urogenital specimens, but culture is commonly used for diagnosis of disseminated infections, including gonococcal arthritis. The Hologic Aptima Combo 2 (AC2), a transcription-mediated amplification assay, is FDA and Health Canada licensed for detection of N. gonorrhoeae and Chlamydia trachomatis from urogenital, rectal, and pharyngeal specimens, but not joint fluid. In the current study, we compared the performance of microscopy, culture, and the AC2 for detection of N. gonorrhoeae from 170 joint fluid specimens. A total of five specimens were culture-positive, whereas 14 were AC2-positive. Gram-negative diplococci, characteristic of

Indexed as

ArthritisChlamydia InfectionsGonorrheaChlamydia trachomatisHumansNeisseria gonorrhoeaeNucleic Acid Amplification TechniquesSensitivity and Specificitydisseminated gonococcal infectionNeisseria gonorrhoeaenucleic acid amplification testing

Identifiers

PMID35317619
PMCPMC9020330
OpenAlexW4220907081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.