Evidence map›Paper›PMID 35317391›Full record

ArticleJournal of geriatric cardiology : JGC2022

Fulminant myocarditis in adults: a narrative review.

Santiago Montero, Darryl Abrams, Enrico Ammirati, Florent Huang, Dirk W Donker, Guillaume Hekimian, Cosme García-García, Antoni Bayes-Genis, Alain Combes, Matthieu Schmidt

Open access · greenAbstract read
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. The role of temporary mechanical circulatory support inJournal of intensive medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Santiago MonteroAcute Cardiovascular Care Unit, Heart Institute, Hospital Germans Trias i Pujol, Departament de Medicina, Universitat Autònoma de Barcelona, CIBERCV, Spain.
Darryl AbramsColumbia University Vagelos College of Physicians & Surgeons/NewYork-Presbyterian Hospital, New York, USA.
Enrico AmmiratiDe Gasperis Cardio Center and Transplant Center, Niguarda Hospital, Milano, Italy.
Florent HuangCardiology, Hôpital Foch, Suresnes, Paris, France.
Dirk W DonkerIntensive Care Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Guillaume HekimianAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Medical Intensive Care Unit, Paris, France.
Cosme García-GarcíaAcute Cardiovascular Care Unit, Heart Institute, Hospital Germans Trias i Pujol, Departament de Medicina, Universitat Autònoma de Barcelona, CIBERCV, Spain.
Antoni Bayes-GenisAcute Cardiovascular Care Unit, Heart Institute, Hospital Germans Trias i Pujol, Departament de Medicina, Universitat Autònoma de Barcelona, CIBERCV, Spain.
Alain CombesAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Medical Intensive Care Unit, Paris, France.
Matthieu SchmidtAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Medical Intensive Care Unit, Paris, France.
Sorbonne Université · FRAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITColumbia University Irving Medical Center · USInserm · FRUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fulminant myocarditis (FM) is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation, often presenting as profound cardiogenic shock, life-threatening ventricular arrhythmias and/or electrical storm. FM may be refractory to conventional therapies and require mechanical circulatory support (MCS). The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis, leading to an increased focus on immunosuppressive treatment strategies. Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM, but that prognosis and management strategies of FM are heavily dependent on histological subtype, placing greater emphasis on the role of endomyocardial biopsy in diagnosis. The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed, including whether MCS is warranted. Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS, with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates, particularly when initiated prior to the development of multiorgan failure. Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies, and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes.

Identifiers

PMID35317391
PMCPMC8915421
OpenAlexW4221067426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.