ArticleWorld journal of psychiatry2022
Associated mortality risk of atypical antipsychotic medication in individuals with dementia.
Article in World journal of psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The consequences of antipsychotic medication use for people living with dementia: a systematic review and meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Exploring the association between antidepressants, progression and mortality in Huntington's disease.Brain : a journal of neurology · 2026Article
- Towards person-centered pain management in dementia: usability of a digital medical device in Portuguese residential care facilities.Frontiers in health services · 2026Article
- Pharmacological management in frontotemporal dementia and patient outcomes: a retrospective cohort study using the TriNetX platform.Frontiers in neurology · 2026Article
- Article
- Akrivia Health Database-deep patient characterisation using a secondary mental healthcare dataset in England and Wales: cohort profile.BMJ open · 2024Article
- Underlying disease may increase mortality risk in users of atypical antipsychotics.World journal of psychiatry · 2022Article
- Natural language processing in Alzheimer's disease research: Systematic review of methods, data, and efficacy.Alzheimer's & dementia (Amsterdam, Netherlands)Review
- Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAntipsychotic medications such as risperidone, olanzapine and aripiprazole are used to treat psychological and behavioural symptoms among dementia patients. Current evidence indicate prescription rates for antipsychotics vary and wider consensus to evaluate clinical epidemiological outcomes is limited.
aimTo investigate the potential impact of atypical antipsychotics on the mortality of patients with dementia.
methodsA retrospective clinical cohort study was developed to review United Kingdom Clinical Record Interactive Search system based data between January 1, 2013 to December 31, 2017. A descriptive statistical method was used to analyse the data. Mini Mental State Examination (MMSE) scores were used to assess the severity and stage of disease progression. A cox proportional hazards model was developed to evaluate the relationship between survival following diagnosis and other variables.
resultsA total of 1692 patients were identified using natural language processing of which, 587 were prescribed olanzapine, quetiapine or risperidone (common group) whilst 893 (control group) were not prescribed any antipsychotics. Patients prescribed olanzapine showed an increased risk of death [hazard ratio (HR) = 1.32; 95% confidence interval (CI): 1.08-1.60;
conclusionA significant mortality risk was identified among those prescribed olanzapine and risperidone which contradicts previous findings although the study designs used were different. Comprehensive research should be conducted to better assess clinical epidemiological outcomes associated with diagnosis and therapies to improve clinical management of these patients.
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