Evidence map›Paper›PMID 35317305›Full record

ArticleNeurotrauma reports2022

Lymphocytes Are Not Required for Neurogenic Heterotopic Ossification Development after Spinal Cord Injury.

Kylie A Alexander, Hsu-Wen Tseng, Irina Kulina, Whitney Fleming, Cedryck Vaquette, François Genêt, Marc J Ruitenberg, Jean-Pierre Lévesque

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kylie A AlexanderMater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
Hsu-Wen TsengMater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
Irina KulinaMater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
Whitney FlemingMater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.
Cedryck VaquetteSchool of Dentistry, The University of Queensland, Herston, QLD, Australia.
François GenêtUPOH (Unité Péri Opératoire du Handicap, Perioperative Disability Unit), Physical and Rehabilitation Medicine department, Raymond-Poincaré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Garches, France.
Marc J RuitenbergGarches Neuro-Orthopaedics Research Group (GRENOG), Garches, France.
Jean-Pierre LévesqueMater Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurogenic heterotopic ossifications (NHOs) are incapacitating complications of traumatic brain and spinal cord injuries (SCI) that manifest as abnormal bone formation in periarticular muscles. Using a unique model of NHO after SCI in genetically unmodified mice, we have previously established that the innate immune system plays a key driving role in NHO pathogenesis. The role of adaptive immune cells in NHO pathogenesis, however, remains unexplored in this model. Here we established that B lymphocytes were reduced in the spleen and blood after SCI and increased in muscles of mice in which NHO develops, whereas minimal changes in T cell frequencies were noted. Interestingly,

Indexed as

B lymphocytesboneneurogenic heterotopic ossificationspinal cord injuryT lymphocytes

Identifiers

PMID35317305
PMCPMC8935476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.