ArticleNeuroscience and behavioral physiology2022
Mechanisms of AMPA Receptor Inhibition by Diminazene.
Article in Neuroscience and behavioral physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- The diversity of AMPA receptor inhibition mechanisms among amidine-containing compounds.Frontiers in pharmacology · 2024Article
- Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.Biomolecules · 2022Review
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Diminazene is an anti-infection agent for animals and is a member of the diarylamidine group. This study reports the first detection of its inhibitory effect on AMPA-type ionotropic glutamate receptors. Experiments were carried out on isolated Wistar rat neurons: striatal giant cholinergic interneurons were used to study calcium-permeable AMPA receptors and hippocampal field CA1 pyramidal neurons were used to study calcium-impermeable AMPA receptors. Cells were isolated by vibrodissociation and currents were recorded by voltage clamping in the whole cell configuration. Diminazene produced concentration-dependent inhibition of currents evoked by application of kainate in both neuron types. IC
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