ArticleWorld journal of gastroenterology2022
Mucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum.
Article in World journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 12 citations in OpenAlex.
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- Optimization of response surface methodology for the extraction of isoliquiritigenin fromFrontiers in pharmacology · 2025Article
- The causality between gut microbiome and chronic regional pain: a Mendelian randomization analysis.Frontiers in microbiology · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundNodular lymphoid hyperplasia (NLH) in the small intestine is a rare benign lesion characterized by multiple small nodules on the intestinal surface. Patients with terminal ileal NLH may experience long-term abdominal pain, diarrhea, and abdominal distension, among other symptoms. Supplementation with probiotics could mitigate these symptoms. NLH is linked to the immune system, and it may result from accumulation of plasma-cell precursors due to a maturational defect during the development of B lymphocytes. The intestinal microbiome plays an essential role in the immune system. Thus, we speculate that the gut flora plays a key role in terminal ileal NLH.
aimTo explore the correlation between intestinal flora and terminal ileal NLH.
methodsWe collected mucosal biopsy samples that were obtained
resultsCompared with the control group, the terminal ileal NLH group showed an increased alpha diversity (
conclusionMaintaining the microbial balance and supplementing targeted protective bacteria could improve symptoms and potentially reduce the risk of lymphoma transformation in patients with terminal ileal NLH.
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