Evidence map›Paper›PMID 35317095›Full record

ArticleBiomaterials and biosystems2021

Endothelial barrier function is co-regulated at vessel bifurcations by fluid forces and sphingosine-1-phosphate.

Ehsan Akbari, Griffin B Spychalski, Miles M Menyhert, Kaushik K Rangharajan, Joseph W Tinapple, Shaurya Prakash, Jonathan W Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials and biosystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ehsan AkbariDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States, 43210.
Griffin B SpychalskiDepartment of Biomedical Engineering The Ohio State University, Columbus, OH, United States, 43210.
Miles M MenyhertDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, United States, 43210.
Kaushik K RangharajanDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States, 43210.
Joseph W TinappleDepartment of Biomedical Engineering The Ohio State University, Columbus, OH, United States, 43210.
Shaurya PrakashDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States, 43210.
Jonathan W SongDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States, 43210.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Biophysical-based approach for controlling blood vessel structure and functionR01HL141941 · NHLBI · OHIO STATE UNIVERSITY · PI CASTRO, CARLOS E., PRAKASH, SHAURYA · 2018 to 2021
$2.0M
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL141941
6 · The paper itself

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid mediator of endothelial barrier function. Prior studies have implicated mechanical stimulation due to intravascular laminar shear stress in co-regulating S1P signaling in endothelial cells (ECs). Yet, vascular networks in vivo consist of vessel bifurcations, and this geometry generates hemodynamic forces at the bifurcation point distinct from laminar shear stress. However, the role of these forces at vessel bifurcations in regulating S1P-dependent endothelial barrier function is not known. In this study, we implemented a microfluidic platform that recapitulates the flow dynamics of vessel bifurcations with in situ quantification of the permeability of microvessel analogues. Co-application of S1P with impinging bifurcated fluid flow, which is characterized by approximately zero shear stress and 38 dyn•cm

Indexed as

Branched microvesselsMechanotransductionMicrofluidic biomimicryVessel permeability

Identifiers

PMID35317095
PMCPMC8936769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.