ArticleArchives of medical science : AMS2022
Omega-6 fatty acids and the risk of cardiovascular disease: insights from a systematic review and meta-analysis of randomized controlled trials and a Mendelian randomization study.
Article in Archives of medical science : AMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Dietary and circulating omega-6 fatty acids and their impact on cardiovascular disease, cancer risk, and mortality: a global meta-analysis of 150 cohorts and meta-regression.Journal of translational medicine · 2025Pooled it
- Omega-3 and Omega-6 Fatty Acids and Cardiovascular Outcomes in Diabetes - A Review of Current Evidence.Current diabetes reports · 2026Review
- Stimulation of Eryptosis and Hemolysis by Adrenic Acid Involves Oxidative Stress, Calcium Elevation, and Metabolic Collapse.International journal of molecular sciences · 2026Article
- Article
- Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health.Nature communications · 2026Article
- Diagnostic and therapeutic potential of serum fatty acids in hyperlipidemia: evidence from three cohorts of patients with coronary atherosclerotic heart disease.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The global burden of ischemic heart disease attributable to trans fatty acid in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.Human genomics · 2026Article
- Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels.Endocrinology, diabetes & metabolism · 2026Article
- Free Fatty Acids Correlate with the Interleukin-1 β and Interleukin-1 Receptor Antagonist in the Early Subacute Phase of Stroke.Biomolecules · 2025Article
- Review
- Adrenic acid: A promising biomarker and therapeutic target (Review).International journal of molecular medicine · 2025Review
- Analysis of cause-specific atherothrombotic cardiovascular disease mortality in Mexico: 2011-2015.Archives of medical science : AMS · 2025Article
- Association between type 1 diabetes mellitus and esophageal varices: a Mendelian randomization study.Archives of medical science : AMS · 2025Article
- The NMR-measured omega-6/omega-3 fatty acid ratio improves cardiovascular risk prediction.Frontiers in nutrition · 2025Article
- Lipidomic Signature of Healthy Diet Adherence and Its Association with Cardiometabolic Risk in American Adults.Nutrients · 2024Article
- Relationship between Polyunsaturated Fatty Acid Metabolism and Atherosclerosis.Reviews in cardiovascular medicine · 2024Review
- Polyunsaturated fatty acids and diabetic microvascular complications: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Summary of 2023 and the biggest challenges for the "Archives of Medical Science" on its 20Archives of medical science : AMS · 2024Article
- Essential Components from Plant Source Oils: A Review on Extraction, Detection, Identification, and Quantification.Molecules (Basel, Switzerland) · 2023Review
- The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence.Nutrients · 2023Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Omega-6 polyunsaturated fatty acids (PUFAs) represent almost 15% of the total energy intake in Western countries. Their effects on the cardiovascular (CV) risk factors are still controversial. Thus, we performed a systematic review and meta-analysis of randomized control trials (RCTs) as well as a Mendelian randomization (MR) analysis to evaluate the links and possible causality between supplementation or serum levels of omega-6 PUFA, CV disease (CVD) and cardiometabolic risk factors. Material and methods: Selected databases were searched until September 2019 to identify prospective studies investigating the effects of omega-6 PUFA supplementation on CVD events/mortality. Random-effects model meta-analysis was performed for quantitative data synthesis. Trial sequential analysis (TSA) was used to evaluate the optimal sample size to detect a 20% reduction in outcomes after administration of omega-6 PUFAs. The inverse variance weighted (IVW) method, weighted median-based method, MR-Egger and MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied for MR. Results: The pooled estimate risk ratio (RR) of omega-6 PUFA supplementation was 0.94 for any CVD event (95% CI: 0.77-1.15, Conclusions: Omega-6 PUFA supplementation did not affect the risk for CVD morbidity and mortality. Additionally, based on MR analysis we found that higher AA levels might even significantly increase the risk of CHD, MI and large artery stroke, as well as the levels of FBG and LDL-C, whereas they were negatively associated with TC and TG. Since a considerable chance of heterogeneity was observed for some of the results, further research is needed to elucidate the effects of omega-6 PUFAs on cardiometabolic outcomes.
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Registered trials
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