Evidence map›Paper›PMID 35316901›Full record

ArticleArchives of medical science : AMS2022

Pure purr virtual reality technology: measuring heart rate variability and anxiety levels in healthy volunteers affected by moderate stress.

Sam Aganov, Eugene Nayshtetik, Vasyl Nagibin, Yuriy Lebed

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Physiological Responses to Virtual Reality-Based Stress Regulation and Relaxation Interventions: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sam AganovDoctor Sam Medical Network, Ukraine.
Eugene NayshtetikPlanexta, California, USA.
Vasyl NagibinBogomoletz Institute of Physiology, National Academy of Sciences (NAS) of Ukraine, Ukraine.
Yuriy LebedPharmaxi LLC, Ukraine.
Bogomoletz Institute of Physiology · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Traditional approaches to stress management are difficult to learn and to implicate in daily life. Emerging technologies like virtual reality (VR) have become a target of extensive study for recreational and medical purposes. The autonomic nervous system (ANS) plays a crucial role in stress response, post-stress relaxation, and recovery. This study aimed to assess the effect of modified VR intervention on short-term heart rate variability (HRV) and perceived anxiety levels in healthy volunteers affected by moderate stress. The stressors included mental arithmetic tasks. Material and methods: The study involved healthy adults, of both sexes, aged 20 to 60 years, without history of cardiovascular diseases, essential abnormalities on ECG, and with normal or moderate level of situational anxiety. The VR gadgets used in the study were commercially available Bobo-VR X1 headsets, one with modification for medical applications (Pure Purr technology) and one with none (sham technology). The investigational (Pure Purr) headset with an audio-visual sequence was modified by adding a binaural effect and was synchronised with the tract of respiratory movements and the frequency of heart rate. To track changes in the ANS, participants underwent both electrocardiography (ECG) and measurement of HRV. Results: The findings showed a significant increase in parasympathetic activity after 5-minute exposure to the investigational device compared to stress, as shown by high-frequency HRV (499.8 ms Conclusions: These findings suggest that a medical device with pre-installed Pure Purr software had a significant effect on the recovery of the ANS in healthy volunteers affected by moderate stress.

Indexed as

heart rate variabilityparasympathetic neurostimulationstressvirtual reality

Identifiers

PMID35316901
PMCPMC8924843
OpenAlexW3008885858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.