Evidence map›Paper›PMID 35316728›Full record

ArticleDNA repair2022

Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4

Zachary Mirman, Keshav Sharma, Thomas S Carroll, Titia de Lange

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zachary MirmanLaboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Keshav SharmaLaboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA.
Thomas S CarrollBioinformatics Resource Center, The Rockefeller University, New York, NY 10065, USA.
Titia de LangeLaboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA. Electronic address: delange@rockefeller.edu.
Rockefeller University · US

Funding

Genome instability in cancer: telomeres and DNA repairR35CA210036 · NCI · ROCKEFELLER UNIVERSITY · PI Titia de Lange · 2016 to 2026
$10.8M
Genome Integrity Through the Cell Cycle in Homeostasis and CancerK00CA245720 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MIRMAN, ZACHARY KENNETH · 2022 to 2025
$397k
Genome Integrity Through the Cell Cycle in Homeostasis and CancerF99CA245720 · NCI · ROCKEFELLER UNIVERSITY · PI MIRMAN, ZACHARY KENNETH · 2019 to 2020
$92k
NCI NIH HHS F99 CA245720NCI NIH HHS K00 CA245720NCI NIH HHS R35 CA210036
6 · The paper itself

Abstract

Double-strand break (DSB) repair relies on DNA damage response (DDR) factors including BRCA1, BRCA2, and RAD51, which promote homology-directed repair (HDR); 53BP1, which affects single-stranded DNA formation; and proteins that mediate end-joining. Here we show that the CRL4/DDB1/WDR70 complex (CRL4

Indexed as

DNA Breaks, Double-StrandedDNA RepairBRCA1 ProteinDNA, Single-StrandedRecombinational DNA RepairTumor Suppressor p53-Binding Protein 1BRCA1 ProteinDNA, Single-StrandedTumor Suppressor p53-Binding Protein 153BP15′ End resectionBRCA1CRL4/DDB1DSB repairHomology-directed repairRAD51WDR70

Identifiers

PMID35316728
PMCPMC9474743
OpenAlexW4220969220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.