Evidence map›Paper›PMID 35316502›Full record

ArticleAdvances in therapy2022

The Association Between Sustained HbA1c Control and Long-Term Complications Among Individuals with Type 2 Diabetes: A Retrospective Study.

Kristina S Boye, Vivian T Thieu, Maureen J Lage, Heather Miller, Rosirene Paczkowski

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Advances in therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830135 (A Multifaceted Telehealth Approach to Enhancing Glycemic Control and Reducing Readmissions in a Diverse Diabetic Population), which is not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830135 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Multifaceted Telehealth Approach to Enhancing Glycemic Control and Reducing Readmissions in a Diverse Diabetic Population: A Randomized Control Trial

TypeinterventionalSponsorWhite Plains HospitalRan2025 to 2027Enrolled208ConditionsDiabetes MellitusArmsContinues glucose monitoring with remote glucose monitoring for 90 days
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  5. Health-related quality of life in racial and ethnic minority adults with type 2 diabetes: validity and responsiveness of the EQ-5D-3L.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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  12. Leveraging Machine Learning to Assess Post-COVID-19 Glycemic Control in Diabetic Patients.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kristina S BoyeEli Lilly and Company, 893 Delaware Street, Indianapolis, IN, 46225, USA.
Vivian T ThieuEli Lilly and Company, 893 Delaware Street, Indianapolis, IN, 46225, USA.
Maureen J LageHealthMetrics Outcomes Research, 17 Benton's Knoll, Guilford, CT, 06437, USA. lagemj@hlthmetrics.com.ORCID http://orcid.org/0000-0003-4961-2027
Heather MillerThe Pennsylvania State University, 535 North Midlothian Road, Mundelein, IL, 60060, USA.
Rosirene PaczkowskiEli Lilly and Company, 893 Delaware Street, Indianapolis, IN, 46225, USA.
Eli Lilly (United States) · USHealth Outcomes Solutions (United States) · USPennsylvania State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe prevalence of type 2 diabetes (T2D) represents a rising burden in the US and worldwide, with the condition shown to be associated with relatively large human and economic costs. Part of the reason for such high costs associated with T2D is that the condition is often accompanied by additional health-related complications. The goal of this research is to examine the association between glycemic control and diabetes-related complications for individuals with T2D.

methodsThe Optum Clinformatics® Data Mart (CDM) database from 2007 to 2020 was used to identify adults with T2D. Individuals were classified as having sustained glycemic control (all hemoglobin A1c [HbA1c] < 7%) or poor glycemic control (all HbA1c ≥ 7%) over the 5-year post-period, and diabetes-related complications were identified based upon the Diabetes Complications Severity Index. Multivariable analyses examined the association between sustained glycemic control and diagnosis of a diabetes-related complication in the post-period.

resultsMaintaining HbA1c < 7% over the 5-year post-period, compared to maintaining HbA1c ≥ 7%, was associated with reduced odds of the diabetes-related complications of cardiovascular disease (odds ratio [OR] = 0.76, 95% confidence interval [CI] 0.61-0.94), metabolic disease (OR = 0.37, 95% CI 0.22-0.600), neuropathy (OR = 0.62, 95% CI 0.45-0.84), nephropathy (OR = 0.81, 95% CI 0.69-0.94), and peripheral vascular disease (OR = 0.52, 95% CI 0.33-0.83). There was no statistically significant association between sustained glycemic control and cerebrovascular disease.

conclusionsSustained glycemic control was found to be associated with significant reductions in the odds of being diagnosed with diabetes-related complications over a 5-year post-period.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 2HyperglycemiaAdultBlood GlucoseGlycated HemoglobinHumansRetrospective StudiesBlood GlucoseGlycated HemoglobinComplicationsDiabetes complications severity indexHemoglobin A1c (HbA1c)Odds ratios (OR)Type 2 diabetes (T2D)

Identifiers

PMID35316502
PMCPMC9056490
OpenAlexW4221077010

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.