Evidence map›Paper›PMID 35316053›Full record

ArticleJournal of the American Chemical Society2022

Synthesis of Cyclohexanones by a Tandem Photocatalyzed Annulation.

Anna V Bay, Emelia J Farnam, Karl A Scheidt

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Deconstructive Radical-Radical Coupling for Programmable Remote Acylation.Angewandte Chemie (International ed. in English) · 2025
    Article
  5. Review
  6. Photochemical reduction of acylimidazolium salts.Beilstein journal of organic chemistry · 2025
    Article
  7. Synthesis and Photocatalytic spMolecules (Basel, Switzerland) · 2024
    Article
  8. Science advances · 2024
    Article
  9. Article
  10. Article
  11. Light-Driven Enantioselective Carbene-Catalyzed Radical-Radical Coupling.Angewandte Chemie (International ed. in English) · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anna V BayDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Emelia J FarnamDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.
Karl A ScheidtDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID 0000-0003-4856-3569

Funding

Therapeutics Development Core (Core B)P30DK114857 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L., QUAGGIN, SUSAN E. · 2018 to 2022
$5.7M
New Cooperative Catalysis Concepts for Asymmetric SynthesisR35GM136440 · NIGMS · NORTHWESTERN UNIVERSITY · PI Karl A Scheidt · 2020 to 2026
$2.9M
NIDDK NIH HHS P30 DK114857NIGMS NIH HHS R35 GM136440
6 · The paper itself

Abstract

The rapid synthesis of cyclic scaffolds is of high importance to the chemistry community. Strategies for the convergent synthesis of substituted carbocycles and heterocycles remain underexplored despite the plethora of applications that these cyclic motifs have in the pharmaceutical and materials industries. Reported herein is a tandem carbene and photoredox-catalyzed process for the convergent synthesis of substituted cycloalkanones via a formal [5 + 1] cycloaddition. Featuring two distinct photoredox cycles and a novel α-oxidation of benzylic ketones, this reaction offers a mild approach to construct two contiguous C-C bonds and eliminates the need for strong bases or expensive metal catalysts. The utility of this method is highlighted through various product diversification reactions that allow access to a range of important cyclic scaffolds.

Indexed as

CyclohexanonesKetonesCatalysisCycloaddition ReactionMetalsCyclohexanonesKetonesMetals

Identifiers

PMID35316053
PMCPMC9050940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.