Evidence map›Paper›PMID 35316026›Full record

ArticleACS applied materials & interfaces2022

Targeted Chemoradiotherapy of Prostate Cancer Using Gold Nanoclusters with Protease Activatable Monomethyl Auristatin E.

Dong Luo, Xinning Wang, Ethan Walker, Sarah Springer, Gopalakrishnan Ramamurthy, Clemens Burda, James P Basilion

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. A Practical, Noninvasive Urine Collection Method for Mice for Large Cohort Preclinical Studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Applications of AuNanomaterials (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Review
  8. Assembling AuJournal of nanobiotechnology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xinning Wang
Ethan Walker
Sarah Springer
Gopalakrishnan Ramamurthy
Clemens Burda
James P Basilion
Case Western Reserve University · US

Funding

Theranostic gold nanoparticles for imaged-guided radical prostatectomy and PDT ablationR01EB020353 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI BASILION, JAMES PETER · 2016 to 2019
$2.7M
PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitizationR01CA260847 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI AYDOGAN, BULENT, BASILION, JAMES PETER · 2021 to 2024
$2.6M
NCI NIH HHS R01 CA260847NIBIB NIH HHS R01 EB020353
6 · The paper itself

Abstract

Combined radiotherapy (RT) and chemotherapy are prescribed to patients with advanced prostate cancer (PCa) to increase their survival; however, radiation-related side effects and systematic toxicity caused by chemotherapeutic drugs are unavoidable. To improve the precision and efficacy of concurrent RT and chemotherapy, we have developed a PCa-targeted gold nanocluster radiosensitizer conjugated with a highly potent cytotoxin, monomethyl auristatin E, PSMA-AuNC-MMAE, for RT and chemotherapy of PCa. This approach resulted in enhanced uptake of NCs by PSMA-positive cancer cells, targeted chemotherapy, and increased efficacy of RT both

Indexed as

GoldProstatic NeoplasmsCell Line, TumorChemoradiotherapyHumansMaleOligopeptidesPeptide HydrolasesXenograft Model Antitumor AssaysGoldmonomethyl auristatin EOligopeptidesPeptide Hydrolaseschemotherapymonomethyl auristatin E (MMAE)prostate cancerPSMA targetingradiosensitizerradiotherapy

Identifiers

PMID35316026
PMCPMC9153066
OpenAlexW4220864098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.