Evidence map›Paper›PMID 35315686›Full record

ArticleAntimicrobial agents and chemotherapy2022

Rifampin Pharmacokinetics/Pharmacodynamics in the Hollow-Fiber Model of Mycobacterium kansasii Infection.

Shashikant Srivastava, Gunavanthi D Boorgula, Jann-Yuan Wang, Hung-Ling Huang, Dave Howe, Tawanda Gumbo, Scott K Heysell

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Mycobacteria susceptibility to epetraborole: how far can it go?The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Shashikant SrivastavaDepartment of Pulmonary Immunology, University of Texas Health Science Center, Tyler, Texas, USA.ORCID 0000-0002-8786-8851
Gunavanthi D BoorgulaDepartment of Pulmonary Immunology, University of Texas Health Science Center, Tyler, Texas, USA.
Jann-Yuan WangDepartment of Internal Medicine, National Taiwan University Hospitalgrid.412094.a, Taipei, Taiwan.ORCID 0000-0003-3406-366X
Hung-Ling HuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Dave HoweQuantitative Preclinical & Clinical Sciences Department, Praedicare, Inc., Dallas, Texas, USA.
Tawanda GumboQuantitative Preclinical & Clinical Sciences Department, Praedicare, Inc., Dallas, Texas, USA.
Scott K HeysellDivision of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA.
Kaohsiung Medical University · TWNational Taiwan University Hospital · TWTexas Tech University · USThe University of Texas Health Science Center at Tyler · USUniversity of Cape Town · ZAUniversity of Virginia · US

Funding

Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and AdultsR01AI137080 · NIAID · UNIVERSITY OF VIRGINIA · PI Scott K Heysell, Leonid Kagan · 2018 to 2026
$6.3M
A randomized clinical trial of early empiric anti-Mycobacterium tuberculosis therapy for sepsis in sub-Saharan AfricaU01AI150508 · NIAID · UNIVERSITY OF VIRGINIA · PI HEYSELL, SCOTT K, MOORE, CHRISTOPHER CHARLES · 2020 to 2024
$3.3M
PK/PD Optimized Cephalosporins Based Treatment Regimens for Children With MDR-TBR01HD099756 · NICHD · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2019 to 2023
$1.6M
Reinforcing old warriors to treat Mycobacterium kansasii in shorter durationR21AI148096 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI KANT, SHASHI · 2020 to 2021
$413k
NIAID NIH HHS R01 AI137080NIAID NIH HHS R21 AI148096NIAID NIH HHS U01 AI150508NICHD NIH HHS R01 HD099756
6 · The paper itself

Abstract

There is limited high-quality evidence to guide the optimal treatment of Mycobacterium kansasii pulmonary disease. We retrospectively collected clinical data from 33 patients with M. kansasii pulmonary disease to determine the time-to-sputum culture conversion (SCC) upon treatment with a standard combination regimen consist of isoniazid-rifampin-ethambutol. Next, MIC experiments with 20 clinical isolates were performed, followed by a dose-response study with the standard laboratory strain using the hollow-fiber system model of M. kansasii infection (HFS-

Indexed as

Lung DiseasesMycobacterium Infections, NontuberculousMycobacterium kansasiiAntitubercular AgentsHumansMicrobial Sensitivity TestsRetrospective StudiesRifampinAntitubercular AgentsRifampinhollow-fiber model systemnontuberculous mycobacteriarifampin

Identifiers

PMID35315686
PMCPMC9017304
OpenAlexW4220801517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.