ArticleJournal of the American Chemical Society2022
Aroyl Fluorides as Bifunctional Reagents for Dearomatizing Fluoroaroylation of Benzofurans.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- AgBFChemical science · 2026Article
- Synthetic methodologies for the chemical recycling of fluorocarbons.Nature reviews. Chemistry · 2026Review
- Cooperative NHC and Photoredox Dual Catalysis for the Construction of Carbonyl Compounds.ACS omega · 2026Review
- Article
- Radical C─H-Aroylation of Allenes via Cooperative Photoredox and N-Heterocyclic Carbene Catalysis.Angewandte Chemie (International ed. in English) · 2025Article
- Palladium-catalyzed intermolecular asymmetric dearomatizative arylation of indoles and benzofurans.Science advances · 2025Article
- Visible light-mediated organocatalyzed 1,3-aminoacylation of cyclopropane employing N-benzoyl saccharin as bifunctional reagent.Nature communications · 2024Article
- Synthesis of Benzofuran Derivatives via a DMAP-Mediated Tandem Cyclization Reaction InvolvingMolecules (Basel, Switzerland) · 2024Article
- Article
- Photochemical dearomative skeletal modifications of heteroaromatics.Chemical Society reviews · 2024Review
- Observation of unusual outer-sphere mechanism using simple alkenes as nucleophiles in allylation chemistry.Nature communications · 2024Article
- Visible Light-Mediated Monofluoromethylation/Acylation of Olefins by Dual Organo-Catalysis.Molecules (Basel, Switzerland) · 2024Article
- Synthetic Advantages of Defluorinative C-F Bond Functionalization.Angewandte Chemie (International ed. in English) · 2023Review
- Recent advances in combining photo- and N-heterocyclic carbene catalysis.Chemical science · 2023Review
- Ketones from aldehydes via alkyl C(spNature communications · 2023Article
- Direct allylic acylation via cross-coupling involving cooperative N‑heterocyclic carbene, hydrogen atom transfer, and photoredox catalysis.Nature communications · 2023Article
- Photoredox cooperative N-heterocyclic carbene/palladium-catalysed alkylacylation of alkenes.Nature communications · 2022Article
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4 authors.
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Abstract
The 2,3-dihydrobenzofuran scaffold is widely found in natural products and biologically active compounds. Herein, dearomatizing 2,3-fluoroaroylation of benzofurans with aroyl fluorides as bifunctional reagents to access 2,3-difunctionalized dihydrobenzofurans is reported. The reaction that occurs by cooperative NHC/photoredox catalysis provides 3-aroyl-2-fluoro-2,3-dihydrobenzofurans with moderate to good yield and high diastereoselectivity. Cascades proceed via radical/radical cross-coupling of a benzofuran radical cation generated in the photoredox catalysis cycle with a neutral ketyl radical formed through the NHC catalysis cycle. The redox-neutral transformation exhibits broad substrate scope and high functional group compatibility. With anhydrides as bifunctional reagents, dearomatizing aroyloxyacylation of benzofurans is achieved and the strategy can also be applied to
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