Evidence map›Paper›PMID 35315603›Full record

Trial reportJournal of Korean medical science2022

A Multi-Center, Double-Blind Randomized Controlled Phase III Clinical Trial to Evaluate the Antiviral Activity and Safety of DA-2802 (Tenofovir Disoproxil Orotate) and Viread (Tenofovir Disoproxil Fumarate) in Chronic Hepatitis B Patients.

Hyung Joon Kim, Ju Hyun Kim, Jong Eun Yeon, Yeon Seok Seo, Jeong Won Jang, Yong Kyun Cho, Byoung Kuk Jang, Byung Hoon Han, Changhyeong Lee, Joon Hyeok Lee and 12 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Korean medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02967939 (Phase III Clinical Trial to Evaluate the Antiviral Activity and Safety of DA-2802), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02967939 phase3completednot on this map

Phase III Clinical Trial to Evaluate the Antiviral Activity and Safety of DA-2802(Tenofovir Disoproxil Orotate) and Viread®(Tenofovir Disoproxil Fumarate) in Chronic Hepatitis B Patients

TypeinterventionalSponsorDong-A ST Co., Ltd.Ran2017 to 2019Enrolled123ConditionsHepatitis B， ChronicArmsDA-2802, Viread®
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 16 institutions in 1 country.

Hyung Joon Kim *Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1165-948X
Ju Hyun Kim *Department of Internal Medicine, Division of Gastroenterology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-8981-135X
Jong Eun YeonDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0510-7371
Yeon Seok SeoDepartment of Internal Medicine, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4171-6331
Jeong Won JangDepartment of Internal Medicine, Catholic University of Korea College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3255-8474
Yong Kyun ChoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9231-006X
Byoung Kuk JangDepartment of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0002-8950-0866
Byung Hoon HanDepartment of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0001-7645-3477
Changhyeong LeeDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0001-5726-8890
Joon Hyeok LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-3547-7434
Jung-Hwan YoonDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9128-3610
Kang Mo KimDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3180-3178
Moon Young KimDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID https://orcid.org/0000-0002-2501-2206
Do Young KimDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-8327-3439
Neung Hwa ParkDepartment of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ORCID https://orcid.org/0000-0002-5648-9189
Eun Young ChoDepartment of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.ORCID https://orcid.org/0000-0003-2604-918X
June Sung LeeDepartment of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Ilsan, Korea.ORCID https://orcid.org/0000-0002-1803-9398
Jin-Woo LeeDepartment of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-7227-4938
In Hee KimDepartment of Gastroenterology, Jeonbuk National University Hospital, Jeonju, Korea.ORCID https://orcid.org/0000-0003-3863-7907
Byung-Cheol SongDepartment of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0002-8319-3375
Byung-Seok LeeDepartment of Internal Medicine, School of Medicine, Chungnam National University, Daejeon, Korea.ORCID https://orcid.org/0000-0002-4669-8892
Oh Sang KwonDepartment of Internal Medicine, Division of Gastroenterology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea. kos@gilhospital.com.ORCID https://orcid.org/0000-0001-9981-3914
Samsung Medical Center · KRGachon University Gil Medical Center · KRKorea University · KRUlsan College · KRYonsei University · KRCatholic University of Korea · KRChung-Ang University · KRChungnam National University · KRDaegu Catholic University · KRJeju National University · KRJeonbuk National University · KRKangbuk Samsung Hospital · KRKeimyung University · KRKosin University Gospel Hospital · KRSeoul National University · KRWonkwang University · KR

Funding

Dong-A ST Co., Ltd
6 · The paper itself

Abstract

backgroundTenofovir disoproxil fumarate (TDF, Viread

methodsThe present study was a double blind randomized controlled trial. Patients with CHB were recruited from 25 hospitals in Korea and given DA-2802 at a dose of 319 mg once daily or Viread

resultsA total of 122 patients (DA-2802 group: n = 61, Viread

conclusionDA-2802 is considered an effective and safe treatment for patients with CHB.

trial registrationClinicalTrials.gov Identifier: NCT02967939.

Indexed as

AdultAntiviral AgentsDose-Response Relationship, DrugDouble-Blind MethodFemaleHepatitis B, ChronicHumansMaleMiddle AgedOrotic AcidRepublic of KoreaTenofovirTreatment OutcomeAntiviral AgentsOrotic AcidTenofovirEfficacyHepatitis B, ChronicHepatitis B VirusSafetyTenofovir

Identifiers

PMID35315603
PMCPMC8938614
OpenAlexW4221046436

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.