Evidence map›Paper›PMID 35315553›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2022

A Readily Scalable, Clinically Demonstrated, Antibiofouling Zwitterionic Surface Treatment for Implantable Medical Devices.

Brian McVerry, Alexandra Polasko, Ethan Rao, Reihaneh Haghniaz, Dayong Chen, Na He, Pia Ramos, Joel Hayashi, Paige Curson, Chueh-Yu Wu and 10 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 48 citations in OpenAlex.

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  14. Electrospun Metal-Organic Framework-Fabric Nanocomposites as Efficient Bactericides.Langmuir : the ACS journal of surfaces and colloids · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Brian McVerryDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Alexandra PolaskoDepartment of Civil and Environmental Engineering, University of California, Los Angeles, CA, 90095, USA.
Ethan RaoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Reihaneh HaghniazCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Dayong ChenDepartment of Materials Science and Engineering, University of California, Los Angeles, CA, 90095, USA.
Na HeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Pia RamosDepartment of Civil and Environmental Engineering, University of California, Los Angeles, CA, 90095, USA.
Joel HayashiCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Paige CursonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Chueh-Yu WuDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Praveen BandaruCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Mackenzie AndersonDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Brandon BuiSilq Technologies, Corp., Los Angeles, CA, 90025, USA.
Aref SayeghDepartment of Urology, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA.ORCID https://orcid.org/0000-0001-9320-2987
Shaily MahendraDepartment of Civil and Environmental Engineering, University of California, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0000-0003-3298-9602
Dino Di CarloDepartment of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Evgeniy KreydinDepartment of Urology, Keck School of Medicine of University of Southern California, Los Angeles, CA, 90033, USA.ORCID https://orcid.org/0000-0001-8207-3809
Ali KhademhosseiniCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0000-0002-2692-1524
Amir SheikhiDepartment of Chemical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Richard B KanerDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.ORCID https://orcid.org/0000-0003-0345-4924
University of California, Los Angeles · USCalifornia NanoSystems Institute · USUniversity of Southern California · USPennsylvania State University · US

Funding

Hemorrhage control in the irreversible anticoagulated patientR01HL137193 · NHLBI · MAYO CLINIC ARIZONA · PI OKLU, RAHMI · 2017 to 2021
$3.0M
Targeted chemotherapy delivery and captureR01EB024403 · NIBIB · MAYO CLINIC ARIZONA · PI KHADEMHOSSEINI, ALI, OKLU, RAHMI · 2017 to 2020
$2.2M
Multifunctional dressing for treatment of diabetic woundsR01GM126831 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI DOKMECI, MEHMET REMZI, TAMAYOL, ALI · 2018 to 2021
$1.3M
National Science Foundation CAREER 1255021National Science Foundation CBET 1337065NHLBI NIH HHS R01 HL137193NIBIB NIH HHS R01 EB024403NIGMS NIH HHS R01 GM126831NIH HHS 1R01EB024403NIH HHS 1R01GM126831NIH HHS HL137193
6 · The paper itself

Abstract

Unlike growth on tissue, microbes can grow freely on implantable devices with minimal immune system intervention and often form resilient biofilms that continuously pump out pathogenic cells. The efficacy of antibiotics used to treat infection is declining due to increased rates of pathogenic resistance. A simple, one-step zwitterionic surface modification is developed to significantly reduce protein and microbial adhesion to synthetic materials and demonstrate the successful modification of several clinically relevant materials, including recalcitrant materials such as elastomeric polydimethylsiloxane. The treated surfaces exhibit robust adhesion resistance against proteins and microorganisms in both static and flow conditions. Furthermore, the surface treatment prevents the adhesion of mammalian fibroblast cells while displaying no cytotoxicity. To demonstrate the clinical efficacy of the novel technology in the real-world, a surface-treated, commercial silicone foley catheter is developed that is cleared for use by the U.S. Food and Drug Administration (K192034). 16 long-term catheterized patients received surface-treated catheters and completed a Patient Global Impression of Improvement (PGI-I) questionnaire. 10 out of 16 patients described their urinary tract condition post implantation as "much better" or "very much better" and 72% (n = 13) of patients desire to continue using the surface-treated catheter over conventional latex or silicone catheters.

Indexed as

BiofilmsSiliconesAnimalsCathetersHumansMammalsProstheses and ImplantsSiliconesantibiofoulingantimicrobial stewardshipcross-linkable coating modificationprotein repellantuniversal surface treatmentzwitterionic surfaces

Identifiers

PMID35315553
PMCPMC9153982
OpenAlexW4220935300

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.