Evidence map›Paper›PMID 35315426›Full record

ArticleActa bio-medica : Atenei Parmensis2022

Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19.

Brandon Michael Henry, Stefanie Benoit, Jens Vikse, Emmanuel Favaloro, Justin Benoit, Giuseppe Lippi

Open access · greenAbstract readLetter
In one paragraph

Article in Acta bio-medica : Atenei Parmensis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brandon Michael HenryDisease Intervention and Prevention and Population Health Programs, Texas Biomedical Research Institute, San Antonio, TX, USA and Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA. brandon.henry@cchmc.org.
Stefanie BenoitDivision of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, OH, USA. stefanie.benoit@cchmc.org.
Jens VikseClinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway. jens.vikse@gmail.com.
Emmanuel FavaloroHaematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology, Westmead Hospital, Westmead NSW, Australia. emmanuelfav@gmail.com.
Justin BenoitDepartment of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA. justinleebenoit@gmail.com.
Giuseppe LippiSection of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy. giuseppe.lippi@univr.it.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is now established to be associated with a thrombotic phenomenon, now called COVID-19 associated coagulopathy (CAC). Anti-Endothelial Cell Antibodies (AECA) are a heterogenous group of autoantibodies targeting various endothelial cell antigens or antigens adhering to endothelial cells, They are commonly observed in a variety of auto-immune and rheumatologic conditions, and were observed in patients with the severe acute respiratory syndrome (SARS) in 2005. We aimed to assess AECA status in patients with COVID-19 and their potential contributing role to endothelial injury and CAC. AECA identification was a relatively infrequent finding in COVID-19 patients on admission, and their presence, albeit in only 2/33 patients, was not associated with disease severity. However, as the autoantibodies were only measured at admission, we cannot exclude the possibility of pathogenic AECA developing later in the course of diseaseFurther studies using additional methods are needed to evaluate the presence and potential pathogenic role of AECA in later stages of COVID-19.

Indexed as

COVID-19Endothelial CellsAutoantibodiesHumansanti-endothelial cell antibodyAutoantibodies

Identifiers

PMID35315426
PMCPMC8972892
OpenAlexW4221048643

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.