ArticleActa bio-medica : Atenei Parmensis2022
Research of the activity of local anesthetics and antiseptics regarding clinical isolates of Acinetobacter baumannii as pathogens of postoperative infectious complications.
Article in Acta bio-medica : Atenei Parmensis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of intravenous morphine and lidocaine on bacterial growth.BMC anesthesiology · 2025Article
- Microbiological substantiation of the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic phlegmon and maxillofacial abscesses.Frontiers in oral health · 2024Article
- The effect of local anesthetics against planktonic forms and film formation ofFrontiers in microbiology · 2023Article
- Decamethoxin and chlorhexidine bigluconate effect on the adhesive and biofilm-forming properties ofFrontiers in oral health · 2023Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbout 60% of all nosocomial infections are caused by microorganisms found in biofilms. Acinetobacter baumannii, as a pathogen of nosocomial infections, occur more frequently in surgical hospitals. The aim of the study was to study the in vitro formation of A. baumannii monotype biofilms under the influence of local anesthetics and antiseptics Materials and methods. The antimicrobial activity of local anesthetics (0.25-0.5%, bupivacaine, 2.0% lidocaine, 0.75% ropivacaine) and antiseptics (decamethoxine 0.1%, octenidine 0.1%, chlorhexidine 0.05%) ) against clinical strains of A. baumannii and studied their ability to produce biofilms.
resultsThe bacteriostatic effect of local anesthetics on A. baumannii within the current concentrations of these drugs, which provide analgesic effect, has been proven. The given results indicate that A.baumanni cultures have a pronounced ability to form biofilms. Clinical strains of opportunistic microorganisms A. baumannii circulating in the hospital environment are highly sensitive to antiseptics decamethoxine and octenidine, chlorhexidine has a weak bactericidal effect against acinetobacteria. The results of studying the effect of local anesthetics on the process of formation of the strain "young" biofilms showed the presence of a dose-dependent effect. The greatest inhibitory activity against "young" biofilms was detected under the combined action of the antiseptic decamethoxine (in concentrations, not exceeding 3.9 μg / ml) and anesthetics (OD-0,199-0,223) (p <0,05).
conclusionsScientific research on various aspects of the formation (or destruction) of bacterial biofilms is a relevant and promising area that will change approaches to the prophylaxis and treatment of a number of infections, including postoperative infectious complications.
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