Evidence map›Paper›PMID 35315272›Full record

ArticleACS chemical biology2022

Comprehensive Mutational Analysis of the Lasso Peptide Klebsidin.

Ethan Hills, Tyler J Woodward, Stanley Fields, Benjamin M Brandsen

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  2. Article
  3. Lasso Peptides-A New Weapon Against Superbugs.International journal of molecular sciences · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ethan HillsDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0003-1025-4293
Tyler J WoodwardDepartment of Chemistry and Biochemistry, Creighton University, Omaha, Nebraska 68178, United States.
Stanley FieldsDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.
Benjamin M BrandsenDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0001-6622-2851
Creighton University · USUniversity of Washington · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI YATES III, JOHN R · 2012 to 2021
$20.7M
Engineering Novel Polyketide AntibioticsF32GM122202 · NIGMS · UNIVERSITY OF WASHINGTON · PI BRANDSEN, BENJAMIN · 2017 to 2018
$116k
NIGMS NIH HHS F32 GM122202NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

Antibiotic resistance is a growing threat to public health, making the development of antibiotics of critical importance. One promising class of potential new antibiotics are ribosomally synthesized and post-translationally modified peptides (RiPPs), which include klebsidin, a lasso peptide from

Indexed as

Escherichia coliPeptidesAnti-Bacterial AgentsDNA-Directed RNA PolymerasesKlebsiella pneumoniaeAnti-Bacterial AgentsDNA-Directed RNA PolymerasesPeptides

Identifiers

PMID35315272
PMCPMC9976627
OpenAlexW4220874310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.