Evidence map›Paper›PMID 35315252›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2-Modulated Canonical Wnt/β-Catenin Signaling.

Xiaobin Han, Zhongjie Sun

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Fibulin 2 Deficiency Drives Epigenetic Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Stem cells for organoids.Smart medicine · 2022
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaobin HanDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.
Zhongjie SunDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.ORCID 0000-0001-6599-1405
University of Tennessee Health Science Center · US

Funding

Investigation into Heart AgingR01AG049780 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2016 to 2020
$2.4M
Epigenetic Regulation of Kidney Function and Blood PressureR01AG062375 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2019 to 2023
$2.3M
Investigation into Arterial Stiffness and HypertensionR01HL154147 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL154147NIA NIH HHS R01 AG049780NIA NIH HHS R01 AG062375NIH HHS AG062375NIH HHS HL154147NIH HHS R01 AG049780
6 · The paper itself

Abstract

Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains unknown. Here, previously unidentified adult kidney Sca1

Indexed as

Pluripotent Stem CellsPodocytesAnimalsbeta CateninEndothelial CellsKidneyMammalsMiceSirtuin 2beta CateninSirtuin 2de novo generationkidney organoidskidney stem cellsSirt2Wnt signaling

Identifiers

PMID35315252
PMCPMC9130916
OpenAlexW4221046469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.