ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2022
Angiography suite cone-beam CT perfusion for selection of thrombectomy patients: A pilot study.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Applications of Conebeam CTP Imaging in Cerebral Disease: A Systematic Review.AJNR. American journal of neuroradiology · 2023Pooled it
- Intra-operative soft tissue perfusion assessment using X-ray angiography images: ischemic stroke study.Medical physics · 2026Article
- Model-based perfusion reconstruction with time separation technique in cone-beam CT dynamic liver perfusion imaging.Medical physics · 2025Article
- Value of Immediate Flat Panel Perfusion Imaging after Endovascular Therapy (AFTERMATH): A Proof of Concept Study.AJNR. American journal of neuroradiology · 2024Article
- Angiography suite cone-beam CT perfusion for selection of thrombectomy patients: A pilot study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
background and purposeThe availability of cone-beam CT perfusion (CBCTP) in angiography suites may improve large-vessel occlusion (LVO) triage and reduce reperfusion times for patients presenting during extended time window. We aim to evaluate the perfusion maps correlation and agreement between multidetector CT perfusion (MDCTP) and CBCTP when obtained sequentially in patients undergoing endovascular therapy.
methodsThis is a prospective, pilot, single-arm interventional cohort study of consecutive patients with anterior circulation LVO. All patients underwent MDCTP and CBCTP prior to endovascular therapy, generating cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time-to-maximum/time to peak contrast concentration maps. We compared the two imaging modalities using three different methods: (1) six regions of interest (ROIs) placed in the anterior circulation territory; (2) ROIs placed in all 10 Alberta Stroke Program Early CT Score regions; and (3) ROI drawn around the entire ischemic area. ROI ratios (unaffected/affected area) were compared for all sequences in each method. We used the intraclass correlation coefficient to calculate the correlation between the studies. Bland-Altman plots were also created to measure the degree of agreement. Finally, a sensitivity analysis was done comparing both modalities in patients with low infarct growth rate.
resultsFourteen patients were included (median age 81 years [74-87], 50% males, median National Institutes of Health Stroke Scale 19 [14-22]). Median time between studies was 42 minutes (interquartile range 29-61). Independently of the method used, we found moderate to excellent correlation in CBF, CBV, and MTT between modalities. CBF correlation further improved in patients with low infarct growth.
conclusionThese results demonstrate promising accuracy of CBCTP in evaluating ischemic tissue in patients presenting with LVO ischemic stroke.
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