ReviewNeurocritical care2022
Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury.
Review in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Cytokines and related signaling pathways in traumatic brain injury.Frontiers in immunology · 2026Review
- EEG criticality as a prognostic tool for functional outcomes in sedated pediatric intensive care patients.Frontiers in computational neuroscience · 2026Article
- Long-Term Postdeployment Clinical Subtypes of Risk and Resiliency in Brain Injury and Neurodegeneration.JAMA network open · 2025Article
- Severe Pediatric Traumatic Brain Injury Presenting Characteristics: Abusive Versus Accidental Trauma.Journal of neurotrauma · 2025Article
- Interleukin-6 and its association with outcome in traumatic brain injury: a prospective cohort.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Group-Based Trajectory Modeling Identifies Distinct Patterns of Sympathetic Hyperactivity Following Traumatic Brain Injury.Neurocritical care · 2025Observational
- Prospective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium.Journal of neurotrauma · 2025Article
- Advancements in the application of multimodal monitoring and machine learning for the development of personalized therapeutic strategies in traumatic brain injury.Frontiers in human neuroscience · 2025Review
- Evolving concepts in intracranial pressure monitoring - from traditional monitoring to precision medicine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Recovery of consciousness after acute brain injury: a narrative review.Journal of intensive care · 2024Review
- Group based trajectory modeling identifies distinct patterns of sympathetic hyperactivity following traumatic brain injury.Research square · 2024Article
- Identification of clinically relevant patient endotypes in traumatic brain injury using latent class analysis.Scientific reports · 2024Article
- Building digital patient pathways for the management and treatment of multiple sclerosis.Frontiers in immunology · 2024Review
- Fluid-Based Protein Biomarkers in Traumatic Brain Injury: The View from the Bedside.International journal of molecular sciences · 2023Review
- Glibenclamide for Brain Contusions: Contextualizing a Promising Clinical Trial Design that Leverages an Imaging-Based TBI Endotype.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Navigating the Ocean of Big Data in Neurocritical Care.Neurocritical care · 2022Article
- Analyzing the Spectrum of mTBI Subgroups.Neurotrauma reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population.
Indexed as
Identifiers
35314969What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.