Evidence map›Paper›PMID 35314968›Full record

ArticleNeurocritical care2022

Left Ventricular Function in the Initial Period After Severe Traumatic Brain Injury in Swine.

Adeyinka Adedipe, Alexander St John, Vijay Krishnamoorthy, Xu Wang, Dominik T Steck, Renata Ferreira, Nathan White, Susan Stern

Abstract read
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Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Adeyinka AdedipeDepartment of Emergency Medicine, Harborview Medical Center, University of Washington, Box 359702, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA. adeyinka@uw.edu.ORCID http://orcid.org/0000-0002-3495-2988
Alexander St JohnDepartment of Emergency Medicine, Harborview Medical Center, University of Washington, Box 359702, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.
Vijay KrishnamoorthyDepartment of Anesthesiology, Duke University Medical Center 3094, Duke University, Durham, NC, 27710, USA.
Xu WangDepartment of Emergency Medicine, Harborview Medical Center, University of Washington, Box 359702, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.
Dominik T SteckDepartment of Anesthesiology and Pain Medicine, University of Washington, Box 356540, 1959 NE Pacific Street, BB-1469, Seattle, WA, 98195-6540, USA.
Renata FerreiraDepartment of Anesthesiology and Pain Medicine, University of Washington, Box 356540, 1959 NE Pacific Street, BB-1469, Seattle, WA, 98195-6540, USA.
Nathan WhiteDepartment of Emergency Medicine, Harborview Medical Center, University of Washington, Box 359702, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.
Susan SternDepartment of Emergency Medicine, Harborview Medical Center, University of Washington, Box 359702, 325 Ninth Avenue, Seattle, WA, 98104-2499, USA.
University of Washington · USDuke Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac dysfunction is common in the days after severe traumatic brain injury (TBI) and may contribute to hypotension episodes, leading to worse outcomes. Little is known about cardiac function in the minutes and hours immediately following TBI. By using fluid percussion TBI in a swine model, we aimed to characterize the immediate post injury cardiac function.

methodsIntubated, anesthetized immature (25.8 ± 1.5 kg) female swine were subjected to severe fluid percussion TBI (4.2 ± 0.2 atm). Beginning at 45 min, simulating hospital arrival, all animals were resuscitated with normal saline (NS), mannitol, and phenylephrine as needed to maintain a cerebral perfusion pressure more than 60 mm Hg and intracranial pressure (ICP) less than 20 mm Hg. Primary outcomes of cardiac function were cardiac output measured by thermodilution and transesophageal echo measurements of cardiac function recorded at prespecified time points and tested for trends over time using linear regression with spline at the time of resuscitation onset. Secondary outcomes included hemodynamic measurements, ICP, and cerebral perfusion pressure.

resultsEighteen animals were included. Post-TBI hemodynamic changes demonstrated an early decrease in mean arterial pressure and cerebral perfusion pressure with a corresponding increase in heart rate and ICP. Immediately after injury, there was a significant decrease in both left atrial area and tissue Doppler imaging e' of the LV lateral wall. In addition, there was a simultaneous increase in LV end diastolic diameter and increase in E/e' ratio of the lateral mitral annulus. All other transesophageal echo measurements demonstrated no significant changes throughout the duration of the experiment.

conclusionsTraumatic brain injury is associated with cardiac dysfunction and increased mortality, however there is still a limited understanding of the hemodynamic and echocardiographic response associated with TBI. In this study we demonstrate the hemodynamic and echocardiographic changes in the early stages of TBI in swine. The authors hope that these results may help better understanding on the management of patients with severe head injury.

Indexed as

Brain InjuriesBrain Injuries, TraumaticHeart DiseasesAnimalsFemaleIntracranial PressureSwineVentricular Function, LeftCardiac dysfunctionTransesophageal echocardiographyTraumatic brain injury

Identifiers

PMID35314968
OpenAlexW4220932790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.