ArticleBrain imaging and behavior2022
Functional connectivity modulations during offset analgesia in chronic pain patients: an fMRI study.
Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The OPRM1 A118G Polymorphism Revisited: Recent Developments and Implications for Personalized Treatment.Current pain and headache reports · 2026Review
- Differential Alterations in Offset Analgesia and Conditioned Pain Modulation in Fibromyalgia: Evidence for Distinct Central Dysregulation.European journal of pain (London, England) · 2026Article
- A review of descending pain modulation in humans.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Beyond pain relief: the effects of chronic opioid use on brain structure and function in diabetic neuropathy-a multimodal neuroimaging study.Diabetologia · 2025Article
- The impact of tetrahydrocannabinol on central pain modulation in chronic pain: a randomized clinical comparative study of offset analgesia and conditioned pain modulation in fibromyalgia.Journal of cannabis research · 2025Article
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- Sleep-Disordered Breathing and Interactions with Opioids: A Narrative Review.Journal of clinical medicine · 2025Review
- Chronic pain is associated with greater brain entropy in the prefrontal cortex.The journal of pain · 2025Article
- Transforming Chronic Pain Management: Integrating Neuromodulation with Advanced Technologies to Tackle Cognitive Dysfunction - A Narrative Review.Journal of pain research · 2025Review
- Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study.Neuroradiology · 2024Article
- From Low-Grade Inflammation in Osteoarthritis to Neuropsychiatric Sequelae: A Narrative Review.International journal of molecular sciences · 2022Review
- Moxibustion for primary dysmenorrhea: A resting-state functional magnetic resonance imaging study exploring the alteration of functional connectivity strength and functional connectivity.Frontiers in neuroscience · 2022Article
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- Abstracts of the 7Molecular painArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with neuropathic pain and fibromyalgia showed reduced or absent offset analgesia (OA) response and attenuated cerebral activity in descending pain modulatory and reward systems in patients. However, neural network modifications of OA in chronic pain have not been determined. We enrolled 23 patients with various chronic pain and 17 age- and gender- matched healthy controls. All participants were given OA-related noxious thermal stimuli, including 3 repeats of offset analgesia paradigm at 46-47-46 °C and constant paradigm at 46 °C on the left volar forearm under whole-brain functional magnitude resonance imaging (fMRI). We evaluated magnitude of OA, examined OA modulated functional connectivity using psychophysiological interaction analysis and resting-state functional connectivity analysis and explored their behavioral correlations in patients compared with controls.Compared to controls, chronic pain patients showed smaller magnitude of OA (P = 0.047). OA modulated connectivity decreased between posterior cingulate cortex (PCC) and right medial prefrontal cortex (MPFC) in proportion to current chronic pain (P = 0.018); decreased between right pallidum and right thalamus, and increased between right caudate nucleus and left primary somatosensory cortex (P
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