ArticleNature2022
Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.
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0cells of the map it votes in
129citing papers in PubMed
18.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
129 citing papers in PubMed, 184 citations in OpenAlex.
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- SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells.PLoS pathogens · 2026Article
- Respiratory virus immune response in the aged host.Immunity & ageing : I & A · 2026Review
- Prostaglandin D2 axis impairs immunity against melanoma via dendritic cells and γδ T cells in middle-aged mice.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.Nature communications · 2026Article
- Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation.Science (New York, N.Y.) · 2026Article
- A murine coronavirus infection platform identifies proviral and proinflammatory activities of SARS-CoV-2 accessory protein 7a.Journal of virology · 2026Article
- Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice.Frontiers in immunology · 2026Article
- Dynamics of lung-infiltrating virus-specific T cells associated with age-dependent SARS-CoV-2 pneumonia severity.PLoS pathogens · 2026Article
- Airway immunometabolic responses during pulmonary bacterial and viral infections.Cell reports · 2025Review
- Article
- Scar wars: the viral menace.American journal of physiology. Lung cellular and molecular physiology · 2025Review
69 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 4 institutions in 3 countries.
Lok-Yin Roy Wong *Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-0727-8289
Jian Zheng *Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Kevin WilhelmsenBIOAGE Labs, Richmond, CA, USA.ORCID http://orcid.org/0000-0001-6518-6369
Kun LiDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Miguel E OrtizDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-5189-4943
Andrew ThurmanDepartment Internal Medicine, University of Iowa, Iowa City, IA, USA.
Alejandro A PezzuloDepartment Internal Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-7544-5109
Peter J SzachowiczDepartment Internal Medicine, University of Iowa, Iowa City, IA, USA.
Pengfei LiDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0001-9062-3735
Ruangang PanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
Klaus KlumppBIOAGE Labs, Richmond, CA, USA.
Fred AswadBIOAGE Labs, Richmond, CA, USA.
Justin ReboBIOAGE Labs, Richmond, CA, USA.
Shuh NarumiyaDepartment of Drug Discovery Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-8062-6529
Makoto MurakamiCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Sonia ZunigaDepartment of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-2549-6826
Isabel SolaDepartment of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
Luis EnjuanesDepartment of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Madrid, Spain.
David K MeyerholzDepartment of Pathology, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-1552-3253
Kristen FortneyBIOAGE Labs, Richmond, CA, USA.
Paul B McCrayDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. paul-mccray@uiowa.edu.ORCID http://orcid.org/0000-0002-4067-577X
Stanley PerlmanDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA. stanley-perlman@uiowa.edu.ORCID http://orcid.org/0000-0003-4213-2354
University of Iowa · USCentro Nacional de Biotecnología · ESKyoto University · JPThe University of Tokyo · JP
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MSARS-CoV Proteins in Heterologous Viral InfectionP01AI060699 · NIAID · UNIVERSITY OF IOWA · PI PERLMAN, STANLEY · 2004 to 2021
$21.5MTRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1MRole of eicosanoids in pathogenic human CoV infectionsR01AI129269 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 2016 to 2026
$4.7MEpigenetic mechanisms of inflammatory memory propagation in human airway epitheliaR01HL163024 · NHLBI · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 2022 to 2026
$2.8MHeat-shock protein 90 modulates goblet cell metaplasia in human airway epitheliaK01HL140261 · NHLBI · UNIVERSITY OF IOWA · PI PEZZULO, ALEJANDRO ANTONIO · 2019 to 2023
$746kNHLBI NIH HHS K01 HL140261NHLBI NIH HHS R01 HL163024NIAID NIH HHS P01 AI060699NIAID NIH HHS R01 AI129269NIAID NIH HHS T32 AI007511NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
Abstract
Coronavirus disease 2019 (COVID-19) is especially severe in aged populations
Indexed as
COVID-19SARS-CoV-2AnimalsEicosanoidsLeukocytes, MononuclearMiceOrganic ChemicalsOxazolesPiperazinesPolyestersProstaglandinsSpike Glycoprotein, CoronavirusSulfonamidesasapiprantEicosanoidsOrganic ChemicalsOxazolesPiperazinesPolyestersProstaglandinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Sulfonamides
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.