ArticleNature2022
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 133 papers.
0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed
20.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
133 citing papers in PubMed, 230 citations in OpenAlex.
- Generation of eight-cell embryo-like cells from human pluripotent stem cells.Nature protocols · 2026Review
- Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation.Protein & cell · 2026Article
- Selective RNA sequestration in biomolecular condensates directs cell fate transitions.Nature biotechnology · 2026Article
- The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026Review
- Transposable Element Activation: A Hallmark of Cancer.Cancer discovery · 2026Review
- Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells.Stem cell reports · 2026Article
- Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human.Nature communications · 2026Article
- A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation.Cell research · 2026Article
- Mitochondrial NADH-redox inflexibility constrains genomic and epigenetic stability in pluripotent stem cells.The EMBO journal · 2026Article
- KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.Genes & development · 2026Article
- Genomic stability of human pluripotent stem cells: advances in research and screening criteria.Stem cells translational medicine · 2026Review
- NELFA supports naïve pluripotency and drives 8C-like state in human embryonic stem cells.Nature communications · 2026Article
- Sensitive monitoring of enhancer and noncoding RNA transcription via ribozyme-assisted RNA editing.Nature communications · 2026Article
- Efficient derivation of stable sheep embryonic stem cells opens a new avenue for agricultural and biomedical application.Journal of advanced research · 2026Article
- Zscan4 enables the formation of the Z compartment.Nature structural & molecular biology · 2026Article
- Species-specific roles of SP1 in bovine and human embryonic genome activation and early embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine.Nature reviews. Molecular cell biology · 2026Review
- Amniogenesis in embryos and stem cell models.Nature cell biology · 2026Review
- Asymmetric division in a two-cell-like state rejuvenates embryonic stem cells.Cell research · 2026Article
- Mechanisms of human germ cell development.Nature reviews. Molecular cell biology · 2026Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
32 authors at 7 institutions in 3 countries.
Md Abdul Mazid *Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. mazid@gibh.ac.cn.ORCID http://orcid.org/0000-0001-7909-4422
Carl Ward *Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0003-0889-9025
Zhiwei Luo *Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Chuanyu Liu *BGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0003-2258-0897
Yunpan LiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yiwei LaiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0003-0733-812X
Liang WuUniversity of Chinese Academy of Sciences, Beijing, China.
Jinxiu LiUniversity of Chinese Academy of Sciences, Beijing, China.
Wenqi JiaLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yu JiangJilin Provincial Key Laboratory of Animal Embryo Engineering, Key Laboratory of Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Hao LiuLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Lixin FuLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yueli YangJilin Provincial Key Laboratory of Animal Embryo Engineering, Key Laboratory of Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
David P IbañezLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Junjian LaiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Xiaoyu WeiUniversity of Chinese Academy of Sciences, Beijing, China.
Juan AnLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Pengcheng GuoJilin Provincial Key Laboratory of Animal Embryo Engineering, Key Laboratory of Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Yue YuanUniversity of Chinese Academy of Sciences, Beijing, China.
Qiuting DengUniversity of Chinese Academy of Sciences, Beijing, China.
Yang WangBGI-Shenzhen, Shenzhen, China.
Ying LiuBGI-Shenzhen, Shenzhen, China.
Fei GaoGenome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-8026-879X
Junwen WangE-GENE, Shenzhen, China.
Shahriar ZamanDepartment of Genetic Engineering and Biotechnology, Faculty of Life and Earth Sciences, University of Rajshahi, Rajshahi, Bangladesh.
Baoming QinLaboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0001-7652-161X
Guangming WuGuangzhou Laboratory, Guangzhou, China.
Patrick H MaxwellCambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0338-2679
Xun XuBGI-Shenzhen, Shenzhen, China.ORCID http://orcid.org/0000-0002-5338-5173
Longqi LiuBGI-Shenzhen, Shenzhen, China. liulongqi@genomics.cn.ORCID http://orcid.org/0000-0002-5828-5542
Wenjuan LiLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. li_wenjuan@gibh.ac.cn.ORCID http://orcid.org/0000-0003-4252-1026
Miguel A EstebanLaboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. miguel@gibh.ac.cn.ORCID http://orcid.org/0000-0002-1426-6809
BGI Group (China) · CNChinese Academy of Sciences · CNJilin University · CNAgricultural Genomics Institute at Shenzhen · CNUniversity of Cambridge · GBUniversity of Rajshahi · BDUniversity of Science and Technology of China · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates a short-lived totipotent state. Understanding the process of totipotency in human cells would have broad applications. However, in contrast to in mice
Indexed as
Embryo, MammalianEmbryonic DevelopmentPluripotent Stem CellsZygoteChromosomal Proteins, Non-HistoneHomeodomain ProteinsHumansTranscription FactorsChromosomal Proteins, Non-HistoneDPPA3 protein, humanHomeodomain ProteinsTPRX1 protein, humanTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.