ArticleNature neuroscience2022
Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- CXCR4 Coordinates Long-Term Olfactory Epithelial Regeneration and Cellular Stress Response After Injury.Molecular neurobiology · 2026Article
- Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering.Nature methods · 2026Article
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- Identifying batch-integrated domains from spatial transcriptomics via graph autoencoder with contrastive learning based on cross-modality and data augmentation.Briefings in bioinformatics · 2026Article
- Article
- Robust characterization and interpretation of rare pathogenic cell populations from spatial omics using GARDEN.Nature communications · 2026Article
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- SEPAR enables spatial metagene discovery and associated molecular pattern characterization in spatial transcriptomics and multi-omics datasets.Communications biology · 2025Article
- Article
- Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis.Glia · 2025Article
- Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering.bioRxiv : the preprint server for biology · 2025Article
- ST-deconv: an accurate deconvolution approach for spatial transcriptome data utilizing self-encoding and contrastive learning.NAR genomics and bioinformatics · 2025Article
- The neurexin gene family regulates olfactory glomerular formation.Cell reports · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- spCLUE: a contrastive learning approach to unified spatial transcriptomics analysis across single-slice and multi-slice data.Genome biology · 2025Article
- 3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary Process Underlying Receptor Gene Expansion and Cellular Divergence of Olfactory Sensory Neurons in Honeybees.Molecular biology and evolution · 2025Article
- Benchmarking algorithms for spatially variable gene identification in spatial transcriptomics.Bioinformatics (Oxford, England) · 2025Article
- STModule: identifying tissue modules to uncover spatial components and characteristics of transcriptomic landscapes.Genome medicine · 2025Article
- STMiner: Gene-centric spatial transcriptomics for deciphering tumor tissues.Cell genomics · 2025Article
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16 authors.
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Abstract
The olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerular positions in the mouse OB. These observations significantly extend earlier studies and suggest an overall organizational principle in the OB that may be used by the brain to assist in odor decoding.
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