ArticleNature biomedical engineering2022
Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window.
Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 212 citations in OpenAlex.
- Localized Temperature Monitoring in Mouse Brain during Light Delivery via a Non-Planar Tapered Fiber-Integrated µRTD Sensor.Advanced materials (Deerfield Beach, Fla.) · 2026Article
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- An ultrasound-scanning in vivo light source.Nature materials · 2026Article
- AI-enabled vascular grafts monitor blood flow.Nature biotechnology · 2026Article
- Sono-mechanical nanostructures-enabled sustained precise ultrasound brain stimulation.Nature communications · 2026Article
- Injectable hydrogel bioelectrostimulator for wireless deep brain neuromodulation.Nature communications · 2026Article
- Atomically Precise Metal Nanoclusters for Near-Infrared-II Photonics.Accounts of chemical research · 2026Article
- NIR-Triggered Upconversion-Perovskite Heterostructures for Non-Genetic, Implant-Free Optoelectronic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Photovoltaic nanoassembly of nanowire arrays sensitized with colloidal nanocrystals for near-infrared retina photostimulation.Science advances · 2026Article
- A self-wrapping, bioresorbable neural interface for wireless multimodal therapy of localized peripheral nerve injury.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Biointerface interaction regulation based on organic semiconducting polymers.Fundamental research · 2026Review
- Regulation of Calcium Ion Channels with Conjugated Molecules for Modulating Biological Functions.ACS central science · 2025Review
- Vibrational Probes in Bioimaging and Chemical Biology.Chemical & biomedical imaging · 2025Article
- Transcranial and precise optical neuromodulation mediated by NIR photoactive nanosheets.Journal of nanobiotechnology · 2025Article
- Boron Difluoride Formazanate Dye With Donor Planarization Engineering for 1060 nm Laser Activated Photothermal Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Base-Mediated Scalable Synthesis of Polybenzothiazoles: Fused-Heterocycle-Engineered Recovery of Precious Metals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Integrating optical neuroscience tools into touchscreen operant systems.Nature protocols · 2025Review
- High-Precision, Low-Threshold Neuromodulation With Ultraflexible Electrode Arrays for Brain-to-Brain Interfaces.Exploration (Beijing, China) · 2025Article
- Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Perspective on Nano-Enabled Photostimulation Biointerfaces.ACS nano · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Neural circuitry is typically modulated via invasive brain implants and tethered optical fibres in restrained animals. Here we show that wide-field illumination in the second near-infrared spectral window (NIR-II) enables implant-and-tether-free deep-brain stimulation in freely behaving mice with stereotactically injected macromolecular photothermal transducers activating neurons ectopically expressing the temperature-sensitive transient receptor potential cation channel subfamily V member 1 (TRPV1). The macromolecular transducers, ~40 nm in size and consisting of a semiconducting polymer core and an amphiphilic polymer shell, have a photothermal conversion efficiency of 71% at 1,064 nm, the wavelength at which light attenuation by brain tissue is minimized (within the 400-1,800 nm spectral window). TRPV1-expressing neurons in the hippocampus, motor cortex and ventral tegmental area of mice can be activated with minimal thermal damage on wide-field NIR-II illumination from a light source placed at distances higher than 50 cm above the animal's head and at an incident power density of 10 mW mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.