ArticleScientific reports2022
Spinal cord microstructural changes are connected with the aberrant sensorimotor cortical oscillatory activity in adults with cerebral palsy.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Motor function and gait decline in individuals with cerebral palsy during adulthood: a narrative review of potential physiological determinants.European journal of applied physiology · 2024Review
- Neurobiological Insights Into Cerebral Palsy: A Review of the Mechanisms and Therapeutic Strategies.Brain and behavior · 2024Review
- Contributions of the sensory system to motor learning : Focus on Cerebral Palsy.Pediatric research · 2024Article
- Adults with cerebral palsy exhibit uncharacteristic cortical oscillations during an adaptive sensorimotor control task.Scientific reports · 2024Article
- Disruption of Sensorimotor Cortical Oscillations by Visual Interference Predicts the Altered Motor Performance of Persons with Cerebral Palsy.Neuroscience · 2024Article
- Motor practice related changes in the sensorimotor cortices of youth with cerebral palsy.Brain communications · 2024Article
- Regular cannabis use alters the neural dynamics serving complex motor control.Human brain mapping · 2023Article
- Attenuated post-movement beta rebound reflects psychomotor alterations in major depressive disorder during a simple visuomotor task: a MEG study.BMC psychiatry · 2023Article
- Inhibitory Synaptic Influences on Developmental Motor Disorders.International journal of molecular sciences · 2023Review
- Spinal cord H-reflex post-activation depression is linked with hand motor control in adults with cerebral palsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Reduced wrist flexor H-reflex excitability is linked with increased wrist proprioceptive error in adults with cerebral palsy.Frontiers in neurology · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Previous animal models have illustrated that reduced cortical activity in the developing brain has cascading activity-dependent effects on the microstructural organization of the spinal cord. A limited number of studies have attempted to translate these findings to humans with cerebral palsy (CP). Essentially, the aberrations in sensorimotor cortical activity in those with CP could have an adverse effect on the spinal cord microstructure. To investigate this knowledge gap, we utilized magnetoencephalographic (MEG) brain imaging to quantify motor-related oscillatory activity in fourteen adults with CP and sixteen neurotypical (NT) controls. A subset of these participants also underwent cervical-thoracic spinal cord MRI. Our results showed that the strength of the peri-movement beta desynchronization and the post-movement beta rebound were each weaker in the adults with CP relative to the controls, and these weakened responses were associated with poorer task performance. Additionally, our results showed that the strength of the peri-movement beta response was associated with the total cross-sectional area of the spinal cord and the white matter cross-sectional area. Altogether these results suggest that the altered sensorimotor cortical activity seen in CP may result in activity-dependent plastic changes within the spinal cord microstructure, which could ultimately contribute to the sensorimotor deficits seen in this population.
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