ArticleScientific reports2022
Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Short-Term Changes in Retinal Activity With Four Myopia Control Spectacle Lenses.Translational vision science & technology · 2026Article
- MyopiaX-1 Safety and Efficacy of a Novel Approach to Slow Juvenile Myopia Progression: A Multicenter, Randomized, Controlled Trial.Ophthalmology science · 2026Article
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- Blue-Light Stimulation for Myopia Prevention: Only Retinal but Not Optic Disc Stimulation Modulates the Pattern ERG.Life (Basel, Switzerland) · 2025Article
- Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia.Bioelectronic medicine · 2024Review
- Increase in choroidal thickness after blue light stimulation of the blind spot in young adults.Bioelectronic medicine · 2024Article
- Enhancement of the Inner Foveal Response of Young Adults with Extended-Depth-of-Focus Contact Lens for Myopia Management.Vision (Basel, Switzerland) · 2024Article
- The influence of the environment and lifestyle on myopia.Journal of physiological anthropology · 2024Review
- Changes in Choroidal Thickness and Retinal Activity with a Myopia Control Contact Lens.Journal of clinical medicine · 2023Article
- Blue-light stimulation of the blind-spot constricts the pupil and enhances contrast sensitivity.PloS one · 2023Article
- Exploration of virtual reality applications in myopia: A systematic review.Advances in ophthalmology practice and researchReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered retinal dopamine and ON-pathway activity may underlie myopia development. It has been shown that the stimulation of the blind spot with short-wavelength light increases the electroretinogram (ERG) b-wave amplitude of myopic eyes and may engage the retinal dopaminergic system. This study evaluated the impact of various durations of blind spot stimulation on the electrophysiological response of the myopic retina and their relationship to axial length. Six myopic individuals underwent three short-wavelength blue light blind spot stimulation protocols (10 s, 1 min, 10 min) using a virtual reality headset. As a control condition, no stimulation was shown for 1 min. The b-wave amplitude of the photopic full-field ERG was measured at baseline and 10, 20, 30, 40, 50, and 60 min after each condition. A significant increase in b-wave amplitude was observed for all stimulation protocols compared to the control. The peak b-wave amplitude was observed 20 min after the 1-min stimulation protocol and 60 min after the 10-min stimulation protocol. A significant positive correlation was found between axial length of the eye and percent change in b-wave amplitude for the 10-min stimulation protocol. A rapid and a delayed b-wave time course responses were observed following 1 min and 10 min of blind spot stimulation, respectively. Overall, these results indicate that light stimulation of the blind spot for various durations elevates ON-bipolar cell activity in the retina and as such is assumed to reduce the myopic response. These findings could have implications for future myopia treatment.
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